Curtana Pharmaceuticals, Inc.

Ambrosio Lopez, Jr

Stanton F McHardy

Graham Beaton

Bismarck Campos

Hua-Yu Leo Wang

Fabio C Tucci

Satheesh Babu Ravula

Francisco Xavier Ruiz

Stanton F Mchardy

Satheesh B Ravula

Francisco Xavier Iii Ruiz

Described herein are compounds and pharmaceutical compositions of phenyl-pyrimidinyl-urea derivatives, which inhibit the activity of Olig2. An example of a phenyl-pyrimidinyl-urea derivative has the following structure: Also described herein are methods using the Olig2 inhibitors for treating cancer and other diseases. The Olig2 inhibitors may be used to treat glioblastoma.

Inhibition of Olig2 activity

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Described herein are urea compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Inhibition of OLIG2 activity

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San Antonio, TX, United States of America

Ambrosio Lopez, Jr