Dartmouth College

Ambrose Cheung

Adhar Manna

Gongyi Zhang

Zhibiao Fu

Guido Memmi

The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in. The compositions also have the ability to inhibit growth ofand as such are useful as antibiotic compounds.

Compositions for treating bacterial infections

The present invention includes compositions and methods for diagnosing and treating CA-MRSA infections in patients. The methods are based on the finding that combining cefoxitin and a synthetic penicillin in a treatment regimen results in a synergistic effect of the two drugs, an effect that is related to PBP4 activity in CA-MRSA isolates. Also provided is a CA-MRSA-specific biomarker which can be used to detect the presence of a CA-MRSA infection in a patient.

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A novel sarR gene and sarR gene product which down regulates the expression of sarA and the resulting virulence determinants inis provided. Methods for modulating the expression of sarA and virulence determinants are also provided. A preferred embodiment of the present invention provides structural information relating to the gene product and enables the identification and formulation of lead compounds and reducements for treating and preventing infections byand related bacteria.

Compositions and methods for affecting virulence determinants in bacteria

A nucleic acid sequence which regulates the autolytic activity of bacteria is provided. Methods for identifying and using agents which interact with the gene to inhibit bacterial growth and infectivity also are provided.

Compositions and methods for identifying agents which regulate autolytic processes in bacteria

A nucleic acid sequence required for regulating the autolytic activity of bacteria is provided. Also provided are polypeptides encoded by the gene or mutant gene as well as vector and host cells for expressing these polypeptides. Methods for identifying and using agents which interact with the gene or mutant gene or polypeptides encoded thereby to inhibit bacterial growth and infectivity are also provided.

Growing community of inventors

Hanover, NH, United States of America

Ambrose Cheung