Genevant Sciences Gmbh

Phaserx, Inc.

University of Washington

Amber E Paschal

Mary Gallagher Prieve

Charbel Diab

Pierrot Harvie

Sean D Monahan

Maher Qabar

Michael S DeClue

Anna Galperin

Debashish Roy

Russell N Johnson

Michael E Houston, Jr

Mary G Prieve

Michael S Declue

Allan Sachs Hoffman

Patrick S Stayton

Anna S Gall

Craig L Duvall

Paul Hickok Johnson

Robert W Overell

Danielle Benoit

Priyadarsi De

Michael E Houston

Robert Overell

Paul Johnson

Anthony J Convertine

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Nucleic acid constructs and methods of using the same

Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.

Heterogeneous polymeric micelles for intracellular delivery

Growing community of inventors

Redmond, WA, United States of America

Amber E Paschal