Regenerative Medical Solutions, Inc.

Mayo Foundation for Medical Education and Research

Amber A Mael

Jon Odorico

Erik Forsberg

Xiaofang Xu

Andre Terzic

Yasuhiro Ikeda

Timothy J Nelson

Almudena J Martinez Fernandez

Satsuki Yamada

Guy Tagliavia

Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.

Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells

This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

Method of treating heart tissue using induced pluripotent stem cells

Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for generating induced pluripotent cells (IPS) from human cells, differentiating the IPS into differentiated cells, and identifying differentiation specific markers.

Markers for differentiation of stem cells into differentiated cell populations

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Madison, WI, United States of America

Amber A Mael