Nuvation Bio Inc.

Medivation Technologies, Inc.

Amantullah Ansari

Sarvajit Chakravarty

Son Minh Pham

Jiyun Chen

Anil Kumar Agarwal

Sreekanth A Ramachandran

Pradeep S Jadhavar

Farha Khan

Varshavekumar S Patil

Michael J Green

Roopa Rai

Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

Heterocyclic compounds as adenosine antagonists

1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

1,8-naphthyridinone compounds and uses thereof

Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. Fused pyrimidine compounds that are inhibitors of Trk receptors (e.g., Trk A, Trk B and Trk C) are provided also. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.

Fused pyrimidine compounds and use thereof

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Noida, India

Amantullah Ansari