Wisconsin Alumni Research Foundation

The Medical College of Wisconsin, Inc.

Amanda Przedpelski

Eric Arthur Johnson

Sabine Pellett

Joseph T Barbieri

William Howard Tepp

William H Tepp

Provided herein are antigenic peptides comprising the SARS-COV-2 spike protein receptor binding domain (CRBD) polypeptide or portions thereof, linked to a non-catalytic, non-toxic tetanus toxin variant (i.e., a modified tetanus toxin or 'MTT') and vaccine compositions comprising the same. In addition, provided herein are methods for making and using CRBD-MTT fusion proteins as immunogenic agents.

COVID-19 vaccine

Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.

Modified clostridial neurotoxins as vaccines and conjugate vaccine platforms

Growing community of inventors

Milwaukee, WI, United States of America

Amanda Przedpelski