Colorado State University Research Foundation

Aximmune, Inc.

Amanda Guth

Steven Dow

Daniel P Regan

Leah Mitchell

Lyndah Chow

Floyd Taub

Terry Opgenorth

Raymond Goodrich

The disclosure provides a cancer vaccine composition comprising inactivated cancer cells and an adjuvant, wherein the inactivated cancer cells are incapable of replication. Also provided is a method for producing a cancer vaccine composition, the method comprising contacting cancer cells with light (e.g., UV light) in the presence of a photosensitizer (e.g., riboflavin).

Cancer vaccine compositions and methods of use thereof

The present disclosure provides methods, kits, and compositions comprising &#x3b2;-alethine and one or more immune modulators and methods to determine when they are advantageous. Particular applications include the use of &#x3b2;-alethine and one or more immune modulators in the treatment of cancer.

Beta-alethine, immune modulators, and uses thereof

The present invention provides cancer stem cell vaccines useful for treating or preventing a variety of tumors, as well as related methods of producing cancer stem cells and antigens thereof and producing vaccine adjuvants with enhanced activity for use with the stem cell vaccines.

Optimized cancer stem cell vaccines

Provided are methods of enhancing an immune response and methods for reducing the recruitment of monocytes to a lymph node by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an antigen. The invention also provides relate methods for amplifying vaccine immunity by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an vaccine. The invention also provides related methods of inhibiting tumor growth and metastasis by administering to an individual with cancer an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an anti-tumor preparation. In addition, related compositions comprising an ARB or a compound of Formula (I) and an antigen, vaccine, or anti-tumor preparation are provided.

Methods and compositions for enhancing an immune response, blocking monocyte migration, amplifying vaccine immunity and inhibiting tumor growth and metastasis

Growing community of inventors

Fort Collins, CO, United States of America

Amanda Guth