Ge Healthcare Limited

Ge Healthcare As

Amanda Ewan

Harry John Wadsworth

Dennis O'Shea

Clare Louise Jones

Ian M Newington

Duncan George Wynn

William John Trigg

Bo Shan

Joanna Marie Passmore

Alessandra Gaeta

James Nairne

Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described. 

Heterocyclic compounds as imaging probes of tau pathology

An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.

Indole derivatives

The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.

Chelating agents

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Amersham, United Kingdom

Amanda Ewan