International Business Machines Corporation

Agency for Science, Technology and Research

3m Innovative Properties Company

Solventum Intellectual Properties Company

Universidad Del Pais Vasco/euskal Herriko Unibersitatea

Universidad Del París Vasco/euskal Herriko Unibertsitatea

Amanda Catherine Engler

James L Hedrick

Yi Yan Yang

Daniel Joseph Coady

Hannah C Cohen

Kimberly A Schommer

Denise J Ziemann

Michael J Turnbull

Joel D Oxman

Yizhong Wang

Jie Yang

Katie Fraass Wlaschin

James M Sieracki

Tiffany T Ton

Victor W L Ng

Julian M W Chan

Jeremy P K Tan

Jeannette M Garcia

Alshakim Nelson

Richard Anthony Dipietro

Tao Gong

Zhan-Yuin Ong

Chuan Yang

Wei Han

Kazuki Fukushima

Mu San Zhang

Jeffrey D Cotton

Shaoqiong Liu

Haritz Sardon

Matthew T Scholz

Audrey A Sherman

Ramesh C Kumar

Gregory Breyta

Richard L Jacobson

Ranjani V Parthasarathy

Kiu-Yuen Tse

Wei Cheng

Robert J Ono

Jed Walter Pitera

Ashlynn L Z Lee

Hareem Tariq Maune

Shrinivas Venkataraman

Xiyu Ke

Haoming Rong

Pei Yun Teo

Rudy J Wojtecki

William Bedingham

Richard G Hansen

Richard Paul Rusin

Richard Anthony DiPietro

Ankit Vora

Nicholas Ransom Powley

John J Rogers

Douglas A Hanggi

Pamela A Percha

Willy Chin

Jennifer N Hanson

Korey W Karls

Michael J Vostal

Jener De Oliveira

Ashlynn Lingzhi Lee

James Patrick DiZio

Adam R Wohl

Jye Yng Teo

Catherine D Heapy

Zhan Yuin Ong

Dale J Case

David Duane Johnson

Elizabeth A Tatroe

Michelle H Stevens

Jeremy Pk Tan

Shao Qiong Liu

Jeremy Pang Kern Tan

Articles that include from 70 wt-% to 99 wt-% of one or more plant based oil that is solid at 25° C., the weight percent based on the total weight of the article; and from 0.5 wt-% to 10 wt-% of fumed silica, the weight percent based on the total weight of the article. Methods of use of the articles are also included.

Oral articles and methods of use

The disclosed tube securement device attaches to the patient's body and to the tube, while allowing for a section of the tube to be detached from the tube securement device. The tube securement device comprises a backing with adhesive coated sections. The backing comprises a first end section, a second end section, and a midsection, separating the first end section from the second end section. The tube securement device further comprises a first adhesive on at least a portion of the first major surface of the first end section, a second adhesive on at least a portion of the first major surface of the second end section, and wherein the first major surface of the midsection is free of tacky adhesive.

Tube securement device

The disclosed reinforced adhesive substrate includes a transparent, flexible, breathable backing with a reinforcing material having open areas to the substrate. The reinforcing material strengthen the breathable backing while maintaining transparency so that overall the substrate is transparent. A transparent adhesive substrate can allow the underlying surface to be visualized.

Reinforced adhesive substrate

An adhesive article including a tie layer and a silicone adhesive is disclosed. The tie layer includes a segmented copolymer having a first segment that is one of (a) a polyether comprising one of PTMO or PEO/PPO or (b) a polysiloxane. The segmented copolymer has a water absorbency of less than about 13%.

Tie layer chemistry to promote bonding with silicone adhesive

Compositions that include: from 5 wt-% to 70 wt-% of one or more plant based oils based on the total weight of the composition; from 35 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; not greater than 7.5 wt-% of one or more surfactants based on the total weight of the composition; and not greater than 3 wt-% of a viscosity modifier of, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.

Oral compositions and methods of use

A method of making a silicone gel adhesive is described comprising providing an acrylic polymer, the acrylic polymer comprising at least 50 wt.-% of polymerized units of C1-C32 (meth)acrylate ester monomer; providing at least one non-functional polydiorganosiloxane, hydroxy-functional polydiorganosiloxane, or a mixture thereof; combining the acrylic polymer and polydiorganosiloxane into a mixture; coating the mixture onto a substrate, and subjecting the mixture to radiation thereby crosslinking the mixture. Also described is a silicone gel adhesive comprising a crosslinked material at least one non-functional polydiorganosiloxane, hydroxy-functional polydiorganosiloxane, or a mixture thereof; and an acrylic polymer comprising at least 50 wt.-% of polymerized units of alkyl (meth)acrylate monomers and a gel content of at least 20 wt.-%. Also described is a medical article or intermediate thereof, comprising a layer of the silicone gel adhesive described herein adhered to a substrate; and methods of adhering a medical article.

Gel adhesive comprising crosslinked blend of polydiorganosiloxane and acrylic polymer

Compositions that include from 0.1 wt-% to 8 wt-% of one or more compounds of formula (I) based on the total weight of the compositionHOCH&#x2014;(CHOH)&#x2014;CHNRR&#x2003;&#x2003;(I)wherein Rand Rare independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R, and SOR; with Rand Rbeing independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; wherein n is an integer from about 2 to about 5; from 5 wt-% to 95 wt-% of one or more plant based oils based on the total weight of the composition; from 5 wt-% to 80 wt-% water based on the total weight of the composition and from 0.01 wt-% to 1 wt-% of one or more nonionic aromatic phenolic preservatives based on the total weight of the composition wherein the composition has a pH from 4.5 to 9.5, the composition is an emulsion, and the composition is edible.

Compositions that include: from 5 wt-% to 30 wt-% of one or more plant based oils based on the total weight of the composition; from 70 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; from 0.1 wt-% to 5 wt-% of one or more surfactants based on the total weight of the composition; and from 0.05 wt-% to 3 wt-% of a viscosity modifier, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.

Securement device

A copolymer composition that includes a silicone copolymer, methods of making the composition, and articles that include the composition, wherein the copolymer composition includes a silicone copolymer having a backbone composition that includes: silicone segments in an amount of 5 wt-% to 40 wt-%, based on the total weight of the silicone copolymer; hydrophilic segments in an amount of 40 wt-% to 75 wt-%, based on the total weight of the silicone copolymer; and reinforcing segments in an amount of 5 wt-% to 30 wt-%, based on the total weight of the silicone copolymer, wherein the reinforcing segments are derived from the reaction of one or more chain extenders with one or more multi-functional isocyanates, multi-functional carboxylic acids, multi-functional anhydrides, multi-functional esters, and/or multi-functional acid halides; wherein the silicone segments, hydrophilic segments, and reinforcing segments are connected through urea, urethane, amide, and/or oxamide linkages; wherein the hydrophilic segments and the reinforcing segments are present in a weight ratio of 1.8:1 to 8:1; and the hydrophilic segments and the silicone segments are present in a weight ratio of 1.3:1 to 4.5:1.

Silicone copolymers, methods of making, and articles

Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Antimicrobial cationic polycarbonates

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San Jose, CA, United States of America

Amanda Catherine Engler