Asterand UK Limited

Amanda Aley

Alexander W Oxford

George Hynd

Kenneth Lyle Clark

Robert Alexander Coleman

Neil Victor Harris

Richard Anthony Borman

Janet Ann Archer

The present invention relates to compounds of formula I: wherein one of Rand Ris selected from the group consisting of H, and optionally substituted Calkyl, Ccycloalkyl, Ccycloalkyl-Calkyl, and phenyl-Calkyl; and the other of Rand Ris an optionally substituted Caryl group; Rand Rare either:(i) independently selected from H, R, R', SOR, C(&#x2550;O)R, (CH)NRR, where n is from 1 to 4 and Rand Rare independently selected from H and R, where R is optionally substituted Calkyl, and R&#x2032; is optionally substituted phenyl-Calkyl, or(ii) together with the nitrogen atom to which they are attached, form an optionally substituted Cheterocyclic group; and their use as pharmaceuticals, in particular for treating conditions alleviated by the antagonism of a 5-HTreceptor.

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Essex, United Kingdom

Amanda Aley