Catabasis Pharmaceuticals, Inc.

Massachusetts Institute of Technology

The Broad Institute, Inc.

Whitehead Institute for Biomedical Research

Milne, Jill C.

Ting, Amal

Jirousek, Michael R.

Vu, Chi B.

Bemis, Jean E.

Amal Ting

Chi B Vu

Michael R Jirousek

Jill C Milne

Jean E Bemis

Benito Munoz

Stephen L Buchwald

Susan Lindquist

Sivaraman Dandapani

Partha Pratim Nag

Benjamin Vincent

Jean-Baptiste Langlois

Raja Srinivas

Willmen Youngsaye

Luke Whitesell

Bruce Tidor

Allison Wensley

Barbara J Morgan

The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be aspecies,species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan cytochrome b and/or fungal or protozoan Hsp90. The present invention also provides synthetic methods of the inventive compounds. 

Indazole derivatives and uses thereof

The invention relates to fatty acid guanidine or salicylate guanidine derivatives; compositions comprising an effective amount of a fatty acid guanidine or salicylate guanidine derivative; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid guanidine or salicylate guanidine derivative.

Fatty acid guanidine and salicylate guanidine derivatives and their uses

The invention relates to fatty acid statin conjugates and fatty acid FXR agonist conjugates; compositions comprising an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate.

Fatty acid conjugates of statin and FXR agonists; compositions and method of uses

The invention relates to fatty acid lenalidomide derivatives; compositions comprising an effective amount of a fatty acid lenalidomide derivative; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid lenalidomide derivative.

Fatty acid lenalidomide derivatives and their uses

The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate.

Fatty acid niacin conjugates and their uses

Growing community of inventors

Newton, MA, United States of America

Amal Ting