Pierre Fabre Medicament

Fundacio Hospital Universitari Vall D'hebron-institut De Recerca

Pierre Fabre Médicament S.a.s.

Amadeo Perez

Pere Tarin

Miguel Angel Asin

Rosa Arola

Eulalia Ferret

Jesus Garcia

Eric Goutay

Montserrat Rutllan

Antonio Rodriguez Sinovas

Ignasi Barba Vert

Miguel-Angel Asin

Neus Bellera Gotarda

Antonio David Garcia-Dorado Garcia

Jésus Garcia

The invention concerns a method for preparing a pharmaceutical composition in the form of microspheres with prolonged release of a water-soluble active principle. The invention is characterized in that it comprises the following successive steps: dissolving an active principle in an appropriate amount of water; emulsifying the resulting aqueous solution of active principle with a d,l-lactide-co-glycolide matrix copolymer, of average molecular weight ranging between 40000 and 80000, dissolved in a chlorinated hydrocarbon, resulting in a first microfine and homogeneous emulsion; emulsifying said resulting first emulsion in an external aqueous phase, containing a surfactant, a viscosity-enhancing agent and an osmotic agent; extraction-evaporation of the solvent to obtain microspheres which are recuperated after filtering, washing and drying. The invention also concerns microspheres obtainable by implementing said method, having continuous release over a period of more than two months, advantageously over a period of at least three months.

Prolonged release biodegradable microspheres and method for preparing same

Biodegradable, controlled-release microspheres and process for preparing

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Barcelona, Spain

Amadeo Perez