American Home Products Corporation

Wyeth

Amadeo A Failli

William Alvin Kinney

Craig E Caufield

Timothy D Ocain

Ghulam N Mir

Katherine L Molnar-Kimber

Christopher A Demerson

Joseph P Sabatucci

Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides monoclonal antibodies specific for rapamycin or a ring opened derivative of rapamycin.

Monoclonal antibodies obtained using rapamycin position 27 conjugates as an immunogen

Rapamycin position 27 conjugates

There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.

2-pyridinecarbothioamides, processes for preparation thereof

2-pyridinecarbothioamides and pharmaceutical compositions comprising the

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1,5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids,

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Princeton, NJ, United States of America

Amadeo A Failli