Kali-chemie Pharma Gmbh

Alwin Sobe

Martin Wischniewski

Berthold Stemmle

Lutz Feicho

Bernd Boedecker

Klaus-Juergen Koelln

Juergen Block

Guenther Kuhnow

Guenter-Josef Peschke

Friederike Henninges

Manfred Rehburg

Pancreatin-containing micropellet cores which can be coated with a gastric juice-resistant film are prepared by extruding a mixture containing pancreatin, polyethylene glycol 4000 and a lower alcohol such as propan-2-ol to produce extrudates which break by themselves into fragments, rounding the fragments with the addition of highly liquid paraffin and drying. Propan-2-ol may be present with the paraffin during rounding. The micropellet cores contain 65-85% pancreatin, and have a bulk density of 0.6 g/ml to 0.85 g/ml, a spherical to ellipsoidal shape with a minor axis in the range of 0.7-1.4 mm and a particle size distribution in which at least 80% of the micropellet cores have a minor axis to major axis ratio in the range from 1:1 to 1:2.

Pancreatin micropellets prepared with polyethylene glycol 4000, paraffin

Coronary affecting medicinal compositions which in addition to a coronary affecting substance selected from the group consisting of isosorbide nitrates and dihydropyridines contain an alkylene glycol ether as a solvent.

Coronary affecting medicinal composition

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Sarstedt, Germany

Alwin Sobe