Denovomatrix Gmbh

Alvin Thomas

Yixin Zhang

Robert Wieduwild

Richard Wetzel

Yong Xu

Dejan Husman

The present invention provides a biomatrix layer comprising, consisting essentially of or consisting of a sulfated oligosaccharide at a concentration in the range of 0.1 &#x3bc;M to 1,000 &#x3bc;M and a peptide-polyethylene glycol-conjugate according to formula (I): PEG-R1-(BX)n (I) wherein B is lysine or arginine, X is selected from alanine, glycine, serine, threonine, tyrosine, glutamic acid or aspartic acid and n is an integer selected from 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and 20; Rmay be absent or is a peptide comprising 5 to 30 amino acids; PEG is comprised at a concentration in the range of 0.1 &#x3bc;M to 1,000 &#x3bc;M; R1, if present, is comprised at a concentration in the range of 0.1 &#x3bc;M to 4,000 &#x3bc;M; (BX)n is comprised at a concentration in the range of 0.25 &#x3bc;M to 1,000 &#x3bc;M. The invention further relates to processes for assembling the biomatrix layer. The biomatrix layer can be used in various biomedical applications, such as neuroprostheses, biosensors, nerve grafts, cell culture and encapsulation of cells and microorganisms as well as for drug delivery.

Non-covalently assembled biomatrix layer

The present invention provides a conductive hydrogel comprising a polystyrene sulfonate compound selected from poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), reduced graphene oxide polystyrene sulfonate (rGO:PSS) and rGO:PEDOT:PSS; and a conjugate of polyethylene glycol (PEG) and a linker-(BX)n oligopeptide of formula (I)PEG-linker-(BX)n&#x2003;&#x2003;(I)

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Dresden, Germany

Alvin Thomas