Beth Israel Deaconess Medical Center, Inc.

Advanced Neuromodulation Systems, Inc.

Children's Medical Center Corporation

Neuroelectrics Barcelona S.l.

Neuroelectronics Barcelona S.l.

Novavision, Inc.

Berenson-allen Center for Noninvasive Brain Stimulation

Alvaro Pascual-Leone

Michael D Fox

Bradford Evan Gliner

Leif R Sloan

W Douglas Sheffield

Patrick J Paul

John R Ives

Giulio Ruffini

Pedro Michael Cavaleiro Miranda

Oscar Ripolles Mateu

Frances E Jensen

David M Himes

Warren Douglas Sheffield

Alexander Rotenberg

Iain Glass

Qun Chen

A system and a method for optimizing the configuration of multisite transcranial current stimulation, including providing an electric field characteristic target map on the brain's cortex, the target map including multiple cortical targets, the multiple cortical targets are localized and/or continuously varying and spatially extended, providing a weight map on the cortical surface prioritizing the important of areas in the target map for the purposes of optimization; and calculating, based on the target and weight maps, optimal currents and optimal locations for a plurality of electrodes intended for providing transcranial current stimulation to globally stimulate at once the multiple cortical targets with excitatory, inhibitory or neutral stimulation.

Method and a system for optimizing the configuration of multisite transcranial current stimulation and a computer-readable medium

Techniques for identifying individual target sites for application of transcranial magnetic stimulation (TMS) to a brain of a patient for treatment of neurological and psychiatric disorders. The identification of the target TMS stimulation sites may be based on using functional connectivity magnetic resonance imaging (fMRI) to determine cortex regions of the brain that are functionally connected to other regions of the brain that may be stimulated to decrease symptoms of depression and other disorders. For example, target stimulation sites may be identified in the left dorsolateral prefrontal cortex (DLPFC) to remotely modulate the activity in a subgenual cingulate region and other limbic regions functionally connected with the DLPFC. TMS may be applied to the patient's head at the identified target TMS sites to treat depression and other neurological and psychiatric disorders.

Identifying individual target sites for transcranial magnetic stimulation applications

Method and devices are provided for treating subjects with Transcranial Magnetic Stimulation (TMS). According to some approaches, the methods and devices are configured for the treatment of ongoing seizures. Other approaches relate to the use of TMS as an antiepileptogenic or for use in determining preferential placement of intracranial probes.

Transcranial magnetic stimulation (TMS) methods and apparatus

Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.

Systems and methods for applying signals, including contralesional signals, to neural populations

Methods for treating and/or collecting information regarding neurological disorders, including language disorders, are disclosed. A method in accordance with one embodiment directing a patient to perform a language-based task, directing information to be collected, with the information corresponding to a level of neural activity in the patient's brain while the patient performs the language-based task, and, based at least in part on the information, selecting a stimulation site within the patient's skull for receiving an electrode coupleable to an electrical current. In further embodiments, at least one electrode can be placed at the stimulation site, and the patient's language disorder can be reduced by applying electrical stimulation directly to the stimulation site via the at least one electrode.

Methods for treating and/or collecting information regarding neurological disorders, including language disorders

Methods for treating and/or collecting information regarding neurological disorders, including language disorders. A method in accordance with one embodiment directing a patient to perform a language-based task, directing information to be collected, with the information corresponding to a level of neural activity in the patient's brain while the patient performs the language-based task, and, based at least in part on the information, selecting a stimulation site within the patient's skull for receiving an electrode coupleable to an electrical current. In further embodiments, at least one electrode can be placed at the stimulation site, and the patient's language disorder can be reduced by applying electrical stimulation directly to the stimulation site via the at least one electrode.

A system for monitoring an electroencephalogram of a patient during administration of transcranial magnetic stimulation including a transcranial magnetic stimulation (TMS) system, an electroencephalogram (EEG) monitoring system, and a control system, coupled between the EEG system and the TMS system, that responds to signals provided by the EEG system and controls the TMS system wherein timing of operation of the TMS system does not need to be synchronized to timing of operation of the EEG system. A conductive plastic electrode system for use with the EEG monitoring system is also provided.

Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation

A method and apparatus for monitoring a magnetic resonance image of a patient during administration of transcranial magnetic stimulation. The method includes the steps of applying transcranial magnetic stimulation (TMS) to a patient using a probe that is substantially constructed of non-ferromagnetic material, monitoring a magnetic resonance image (MRI) of the patient during TMS wherein application of the TMS does not need to by synchronized to monitoring of the MRI.

Growing community of inventors

Wayland, MA, United States of America

Alvaro Pascual-Leone