Wave Life Sciences Ltd.

Alvaro Andres Lanao

Chandra Vargeese

Genliang Lu

Naoki Iwamoto

Subramanian Marappan

Christopher P Hencken

David Charles Donnell Butler

Pachamuthu Kandasamy

Sethumadhavan Divakaramenon

Gopal Reddy Bommineni

Mamoru Shimizu

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

Compounds, compositions and methods for synthesis

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Middlebury, CT, United States of America

Alvaro Andres Lanao