Chiron Corporation

Nuvelo, Inc.

Novartis Vaccines & Diagnostics, Gmbh

Altaf Kassam

Christoph Reinhard

David Pot

Lewis T Williams

Pablo Dominguez Garcia

George Lamson

Radoje Drmanac

Giulia C Kennedy

Snezana Drmanac

Michael A Innis

Klaus Giese

David B Kita

Jaime A Escobedo

Filippo M Randazzo

Ivan Labat

Julie Sudduth-Klinger

Birgit Stache-Crain

Veronica Garcia

Lee William Jones

Radomir Crkvenjakov

Mark Dickson

Dena Leshkowitz

Tasha Marenbach

The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

Gene products differentially expressed in cancerous cells and their methods of use II

This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

Human genes and gene expression products V

Human genes and gene expression products II

A human gene encoding a novel mitogen-activated (MAP) kinase kinase, MKK7, provides methods and reagents for treating a variety of MKK7-mediated disorders, such as ischemic heart disease, kidney failure, oxidative liver damage, respiratory distress syndrome, heat and radiation burns, septic shock, autoimmune disorders, and inflammatory diseases. MKK7 reagents can also be used to induce or prevent apoptosis.

Mitogen-activated protein kinase kinase 7 (MKK7)

A human gene encoding a novel cyclin-dependent kinase termed hPFTAIRE and its expression products can be used to provide reagents and methods for detecting migrating or metastasizing cells. Compositions and methods for treating proliferative disorders and neoplasia are also provided.

Polynucleotides encoding human cyclin-dependent kinase (hPFTAIRE)

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Oakland, CA, United States of America

Altaf Kassam