International Business Machines Corporation

Agency for Science, Technology and Research

The University of Mons-hainaut

Globalfoundries Inc.

Nanomalaysia Berhad

Alshakim Nelson

James L Hedrick

Ratnam Sooriyakumaran

Qinghuang Lin

Phillip Joe Brock

Blake W Davis

Robert Dennis Miller

Robert David Allen

Daniel Sanders

Jitendra Singh Rathore

Jeannette M Garcia

Rudy J Wojtecki

Yi Yan Yang

Amanda Catherine Engler

Daniel Joseph Coady

Hareem Tariq Maune

Qiu Dai

Dylan J Boday

Sampath Purushothaman

Young-Hye Na

Ankit Vora

Wei Han

Kazuki Fukushima

Mu San Zhang

Wu-Song S Huang

Gregory Breyta

David Berman

Russell Clayton Pratt

Luisa Dominica Bozano

Robert J Ono

Julian M W Chan

Shaoqiong Liu

Steven J Holmes

Matthew Earl Colburn

Dirk Pfeiffer

Satyanarayana Venkata Nitta

Wayne Isami Imaino

Robert L Bruce

Joy Cheng

Linda Karin Sundberg

Pierre-Olivier Jubert

Victoria A Piunova

Chuan Yang

William Marvin Dyer

Geraud Jean-Michel Dubois

Delia J Milliron

Julia Elizabeth Rice

Joseph Sly

Jed Walter Pitera

James Lupton Hedrick

Krishna M Bajjuri

Jye Yng Teo

Philippe Dubois

Olivier Coulembier

Fabian Suriano

Mohd Zulkefeli Bin Mat Jusoh

Krishna S Bajjuri

The present invention relates to a water-soluble polymer complex that includes a water-soluble block copolymer and a magnetic nanoparticle, wherein the water-soluble polymer complex has a nonzero net magnetic moment in the absence of an applied magnetic field at ambient temperatures. The water-soluble block copolymer is preferably a diblock or triblock copolymer and the magnetic nanoparticle is preferably a ferrimagnetic or ferromagnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules. Exemplary water-soluble polymer complexes covered under the scope of the invention include PEG-b-PAAmodified CoFeO; NH-PEG-b-PAAmodified CoFeO; PNIPAM-b-PAAmodified CoFeO; and mPEG-b-PCL-b-PAA modified CoFeO.

Aqueous soluble ferrimagnets stabilized by block copolymers

Star polymer occlusion complexes were prepared comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent amphiphilic polymer arms, ii) a nutraceutical (such as coenzyme Q10), and iii) a cholesterol-lowering drug (such as simvastatin). An initial occlusion complex formed with the nutraceutical and the star polymer exhibited improved binding properties for the cholesterol-lowering drug, resulting in improved loading efficiencies for the cholesterol-lowering drug. The star polymer occlusion complexes have utility in the medical treatment of high blood cholesterol.

Co-delivery of cholesterol lowering drugs and nutraceuticals

This application describes methods of forming an object. The methods described include forming a mixture with i) one or more primary diamines, ii) one or more polymerizable monomers, iii) a formaldehyde-type reagent, and iv) a polymerization initiator; forming a gel by heating the mixture to a temperature of at least 50&#xb0; C.; and curing the one or more polymerizable monomers by activating the polymerization initiator. The one or more primary diamines may include one or more amine functional oligomers and/or primary aromatic diamine small molecules. The one or more polymerizable monomers may include styrenics, acrylates, methacrylates, vinyl esters, unsaturated polyesters, and derivatives thereof. The gel is a polyhemiaminal (PHA), a polyhexahydrotriazine (PHT), and/or a polyoctatriazacane (POTA) polymer, and curing of the gel forms an interpenetrating network of the PHA/PHT/POTA and the polymer formed from the polymerizable monomers.

3D printing with PHT/PHA based materials and polymerizable monomers

A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.

Condensation polymers for antimicrobial applications

This application describes methods of forming an object. The methods described include flowing a polyhemiaminal (PHA), polyhexhydrotriazine (PHT), or polyoctatriazacane (POTA) precursor mixture to a nozzle of a 3D printer, heating the PHA, PHT, or POTA precursor to a temperature of at least 50&#xb0; C., dispensing the PHA, PHT, or POTA precursor in a pattern; and, hardening the PHA, PHT, or POTA precursor into a polymer. The PHA and PHT polymers are formed by reacting a primary diamine with a formaldehyde-type reagent. The POTA polymer is formed by reacting a primary diamine with a formaldehyde-type reagent and formic acid. The objects formed using the methods described herein may be made of a single polymer, a single polymer type using multiple diamine monomers, or a mixture of PHA, PHT, and/or POTA polymers with different desired physical properties.

3D printing with PHT based materials

A thermo-responsive shear-thinning photo-curable composition comprises water, a linear amphiphilic polyether ABA triblock copolymer comprising at least one pendent ene group (*&#x2014;CH&#x2550;CH) capable of undergoing a thiol-ene reaction, a water-soluble crosslinking agent comprising two or more methylenethiol groups (*&#x2014;CHSH), and a photoinitiator. Under non-shear conditions and a triblock copolymer concentration suitable for direct-write printing, the composition is a viscoelastic solid (hydrogel) at a temperature of about 15&#xb0; C. to about 45&#xb0; C., and is a free-flowing liquid (sol) between 0&#xb0; C. and about 10&#xb0; C. The hydrogel form can be shear-thinned at about 15&#xb0; C. to about 45&#xb0; C. to form a sol suitable for a direct-write printer using an extruding print-head. The compositions covalently crosslink when flood-exposed to ultraviolet radiation. The compositions have utility in forming three-dimensional scaffolds for growing living cells.

Hydrogel compositions for direct-write printing applications

Methods to form a polymer by ring-opening polymerization include reacting, a mixture comprising a monomer, an accelerator, an initiator, and a catalyst comprising a 1,1,1,3,3,3-hexafluoropropan-2-ol-2-yl group to form the polymer. Also disclosed are polymers including a residual amount of the catalyst in an amount greater than 0 weight percent.

Method of ring-opening polymerization, and related compositions and articles

A method comprises disposing, on a porous support membrane, an aqueous mixture comprising a crosslinkable polymer comprising a poly(meth)acrylate and/or poly(meth)acrylamide backbone, thereby forming an initial film layer, wherein the crosslinkable polymer comprises a side chain nucleophilic amine group capable of interfacially reacting with a multi-functional acid halide crosslinking agent to form a crosslinked polymer; contacting the initial film layer with a mixture comprising i) the multi-functional acid halide crosslinking agent, ii) an optional accelerator, and iii) an organic solvent, the organic solvent being a non-solvent for the crosslinkable polymer; and allowing the crosslinkable polymer to interfacially react with the crosslinking agent, thereby forming a composite filtration membrane comprising an anti-fouling selective layer comprising the crosslinked polymer.

Composite filtration membranes and methods of preparation thereof

An interconnect structure includes a patterned and cured dielectric layer located directly on a surface of a patterned permanent antireflective coating. The patterned and cured dielectric layer and the permanent antireflective coating form shaped openings. The shaped openings include an inverse profile which narrows towards a top of the shaped openings. A conductive structure fills the shaped openings wherein the patterned and cured dielectric layer and the permanent antireflective coating each have a conductively filled region.

Interconnect structure and method for fabricating on-chip interconnect structures by image reversal

Silsesquioxane polymers, silsesquioxane polymers in negative tone photo-patternable dielectric formulations, methods of forming structures using negative tone photo-patternable dielectric formulations containing silsesquioxane polymers, and structures made from silsesquioxane polymers.

Photo-patternable dielectric materials and formulations and methods of use

Silsesquioxane polymers that cure to porous silsesquioxane polymers, silsesquioxane polymers that cure to porous silsesquioxane polymers in negative tone photo-patternable dielectric formulations, methods of forming structures using negative tone photo-patternable dielectric formulations containing silsesquioxane polymers that cure to porous silsesquioxane polymers, structures containing porous silsesquioxane polymers and monomers and method of preparing monomers for silsesquioxane polymers that cure to porous silsesquioxane polymers.

Photo-patternable dielectric materials curable to porous dielectric materials, formulations, precursors and methods of use thereof

A method of preparing particles comprises forming by optical lithography a topographic template layer disposed on a surface of a substrate, which is suitable for spin casting. The template layer comprises a non-crosslinked template polymer having a pattern of independent wells therein for molding independent particles. Spin casting a particle-forming composition onto the template layer forms a composite layer comprising the template polymer and the particles disposed in the wells. The composite layer is removed from the substrate using a stripping agent that dissolves the template polymer without dissolving the particles. The particles are then isolated.

Methods of forming nanoparticles using semiconductor manufacturing infrastructure

Growing community of inventors

Fremont, CA, United States of America

Alshakim Nelson