California Institute of Technology

Gwangju Institute of Science and Technology

Alphonsus Hon-Chung Ng

James R Heath

Songming Peng

Sung Jae Yang

Jongchan Choi

William Chour

Ji-Chul Hyun

Compositions and methods for identifying antigen-specific T cells, including determining paired T cell receptor sequences for a specific antigen, are described. Compositions and methods for identifying neoantigen-specific T cells are also described. Microfluidic devices useful for identifying antigen-specific T cells, and methods of using the same, are also described.

Pairing antigen specificity of a T cell with T cell receptor sequences

Disclosed herein are methods and devices for antigen-specific T cell identification or neoantigen identification. Also disclosed herein are devices for separating and isolating antigen-specific T cells or other particles of a certain size from a population of particles of different sizes. Also describe herein are methods and devices for the separation and isolation of barcoded T cells from other nanoparticles containing barcodes for subsequent analysis and further processing of a viable T cell.

Microfluidic devices and methods for purifying rare antigen-specific T cell populations

Growing community of inventors

Pasadena, CA, United States of America

Alphonsus Hon-Chung Ng