Endospan Ltd.

Brainsgate Ltd.

Nicast Ltd.

Estimme Ltd.

Samson Neurosciences Ltd.

Paindure Ltd.

Braingate Ltd.

Japan Lifeline Co., Ltd.

Alon Shalev

Yaniv Marmur

Yossi Gross

Raphael Benary

Rafi Benary

Sagi Raz

Nir Shalom Nae

Or Zigelboim

Adi Lorian

Amir Natan

Hernan Altman

Alexander Dubson

Avinoam Dayan

Ori Nissan

Itschak Lamnsdorf

Leonid Degtyar

A stent-graft () comprises strut members () and a graft member (), which is fixed to the strut members (). The strut members () and the graft member () are arranged so as to define, when the stent-graft () is in a radially-expanded state: a main tube (), which is shaped so as to define a main lumen (); and a lateral tube (), which (a) has (i) a distal end () and (ii) a proximal end () that is joined to a lateral wall () of the main tube () at a junction (), (b) is shaped so as to define a lateral lumen () that is in fluid communication with the main lumen (), and (c) defines a central longitudinal axis (). The strut members () that define the lateral tube () are shaped so as to define two to four non-contiguous arcuate members (), which (a) are centered around the central longitudinal axis (), and (b) collectively subtend at least 150 degrees around the central longitudinal axis ().

Endovascular stent-graft with fatigue-resistant lateral tube

An elongate delivery shaft assembly () includes an outer covering shaft () and an inner support shaft (). When the delivery shaft assembly () is unconstrained and a stent-graft () is removably constrained in a radially-compressed delivery state along a distal end portion () of the delivery shaft assembly (), radially between the outer covering shaft () and the inner support shaft (): (a) the delivery shaft assembly () is shaped so as to define a self-orienting portion (), which (i) is shaped so as to define at least proximal and distal curved portions (A,B), the proximal curved portion (A) disposed more proximal than the distal curved portion (B), and (ii) at least one point of inflection () on a central longitudinal axis () of the delivery shaft assembly () longitudinally between the proximal and the distal curved portions (A,B), and (b) respective smallest radii of curvature of the proximal and the distal curved portions (A,B), measured at the central longitudinal axis (), are each between 2.5 and 12 cm.

Self-orienting endovascular delivery system

First and second stent-grafts are provided. The first stent-graft defines a first lateral opening, and is configured for positioning a first end thereof in a descending aorta, and a second end thereof in one of the branches of an aortic arch, with the first lateral opening disposed in the aortic arch facing upstream. The second stent-graft includes a second generally tubular support element and a second covering element that partially covers the second support element. The first and the second stent-grafts are configured such that the second stent-graft forms a blood-impervious seal with the first stent-graft around the first lateral opening when the second stent-graft is disposed therethrough such that a proximal portion of the second support element is disposed within the first stent-graft. The second covering element does not fully cover the proximal portion, thereby allowing blood flow through the first stent-graft. Other embodiments are also described.

Multi-component stent-graft system for implantation in a blood vessel with multiple branches

An endovascular system includes an elongate delivery shaft assembly, which, when a stent-graft is removably constrained in a radially-compressed delivery state along a distal end portion of the delivery shaft assembly, is shaped so as to define a self-orienting portion, which is shaped so as to define (a) at least proximal and distal curved portions, the proximal curved portion disposed more proximal than the distal curved portion, and (b) at least one point of inflection on a central longitudinal axis of the delivery shaft assembly longitudinally between the proximal and the distal curved portions. Upon positioning of a distal tip of the system near a bifurcation of a brachiocephalic artery from an aortic arch, the self-orienting portion automatically rotationally orients itself in the aortic arch to a rotational orientation in which an inferior lateral opening of the stent-graft faces upstream in the aortic arch. Other embodiments are also described.

A stent-graft () comprises strut members () and a graft member (), which is fixed to the strut members (). The strut members () and the graft member () are arranged so as to define, when the stent-graft () is in a radially-expanded state: a main tube (), which is shaped so as to define a main lumen (); and a lateral tube (), which (a) has (i) a distal end () and (ii) a proximal end () that is joined to a lateral wall () of the main tube () at a junction (), (b) is shaped so as to define a lateral lumen () that is in fluid communication with the main lumen (), and (c) defines a central longitudinal axis (). The strut members () that define the lateral tube () are shaped so as to define two to four non-contiguous arcuate members (), which (a) are centered around the central longitudinal axis (); and (b) collectively subtend at least 150 degrees around the central longitudinal axis ().

A method for treating a subject includes providing an endovascular system that includes a stent-graft and an elongate delivery shaft assembly. When the delivery shaft assembly is unconstrained and the stent-graft is removably constrained along a distal end portion of the delivery shaft assembly, the delivery shaft assembly is shaped so as to define a self-orienting portion, which is shaped so as to define at least proximal and distal curved portions. The delivery shaft assembly is transvascularly introduced into a descending aorta of the subject and a distal end of the delivery shaft assembly is advanced to an aortic arch, such that the self-orienting portion assumes a desired rotational orientation in the aortic arch. While the distal end of the delivery shaft assembly is positioned in the aortic arch, the stent-graft is released from the distal end portion of the delivery shaft assembly. Other embodiments are also described.

Apparatus is provided for use with a delivery catheter, including a primary stent-graft and a flared endovascular stent-graft, which is configured to initially be positioned in the delivery catheter in a radially-compressed state, and to assume a radially-expanded state upon being deployed from the delivery catheter. The primary stent-graft includes: a structural member, which includes a plurality of structural stent elements, and which, when the flared endovascular stent-graft assumes the radially-expanded state, is shaped so as to define a flared caudal portion, which flares radially outward in a caudal direction; at least one biologically-compatible substantially fluid-impervious flexible sheet, which is coupled to at least the flared caudal portion; and a stent-engagement member, which is generally tubular when the flared endovascular stent-graft assumes the radially-expanded state, which is disposed at least partially within the flared caudal portion, and which is configured to be sealingly coupled to the primary stent-graft.

Vascular prosthesis for treating aneurysms

An endovascular stent-graft is provided that includes a flexible stent member and a tubular fluid flow guide. The tubular fluid flow guide includes first and second fabrics. The first fabric includes a first biologically-compatible substantially blood-impervious material, and is attached to and covers the stent member along a first longitudinal portion of the stent-graft. The second fabric includes a second biologically-compatible substantially blood-impervious material different from the first material, and is attached to and covers the stent member along a second longitudinal portion of the stent-graft. The second longitudinal portion is at least partially non-longitudinally-overlapping with the first longitudinal portion. Other embodiments are also described.

Multi-fabric endovascular stent-graft

An endovascular prosthesis includes a stent-graft and an external coagulation inducer. The stent-graft includes a first portion of structural strut members and a first portion of a graft member, which, when the endovascular prosthesis is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer includes an extra-luminal skirt, which includes a second portion of the structural strut members and a second portion of the graft member, and is configured to assume: (i) when the endovascular prosthesis is removably disposed in a delivery sheath, a radially-compressed delivery state, in which the structural strut members of the first portion do not coincide with the structural stent members of the second portion, and (ii) when the endovascular prosthesis is unconstrained, a radially-expanded state, in which the extra-luminal skirt extends radially outward from an external surface of the stent-graft.

Stent-grafts systems with skirt

A multi-component stent-graft system is provided, which includes a first stent-graft, which is configured to assume radially-expanded and radially-compressed states; and a second stent-graft, which is configured to assume radially-expanded and radially-compressed states. A delivery tool includes an outer tube, in which the first and the second stent-grafts are initially positioned at respective axial sites within the outer tube, in their radially-compressed states without being fixed to each other. Other embodiments are also described.

A multi-component stent-graft system includes a first stent-graft, and second, third, and fourth branching stent-grafts. The first stent-graft is shaped so as to define, when in a radially-expanded state, proximal and distal superior first lateral openings facing in a first radial direction, and a distal inferior first lateral opening facing a second radial direction generally opposite the first radial direction. The second, third, and fourth branching stent-grafts are configured assume radially-expanded states, wherein the first, the second, the third, and the fourth stent-grafts are configured such that the branching stent-grafts form respective blood-impervious seals with the first stent-graft around the distal inferior first lateral opening, the distal superior first lateral opening, and the proximal superior first lateral opening, respectively, when the branching stent-grafts are disposed therethrough, respectively, and the first, the second, the third, and the fourth stent-grafts are in their radially-expanded states.

An endovascular system () includes an endovascular implant () and a delivery tool (). The implant () is configured to assume a radially-compressed delivery state, and a radially-expanded deployment state. The delivery tool () includes a proximal main delivery catheter (), having a distal portion () in which the implant () is disposed while in the radially-compressed delivery state; and a distal restraining assembly (), which includes a restraining-assembly tubular shaft () disposed distal to the proximal main delivery catheter (). The distal restraining assembly () is configured to assume an engaged state, in which the distal restraining assembly () prevents proximal displacement of the implant () relative to the distal restraining assembly (), and a disengaged state, in which the distal restraining assembly () allows proximal displacement of the implant () relative to the distal restraining assembly (). Other embodiments are also described.

Minimization of stent-graft migration during implantation

An endovascular stent-graft is provided that includes a structural member, which includes structural stent elements, at least a portion of which define a stent body when the stent-graft assumes a radially-expanded state; and a fluid flow guide. When the stent-graft assumes the radially-expanded state, (a) a first subset of the structural stent elements are configured to cause the stent body and the fluid flow guide to define a bulge that extends radially outward and has a greatest cross-sectional area that is equal to at least 120% of a cross-sectional area of a narrowest portion of the stent-graft rostral to the bulge, and (b) a second subset of the structural stent elements are not configured to cause the fluid flow guide to define the bulge. The structural stent elements of the first subset at least partially overlap the structural stent elements of the second subset lengthwise along the stent body.

An extra-luminal ring () includes a structural member (), which assumes a first elongate hollow shape () when in a relaxed state; when deformed to a planar state (), generally defines a planar shape () having two first sides (A,B) parallel to each other, and two second sides (A,B) parallel to each other; and when in the relaxed state, is configured such that the two first sides (A,B) are generally straight and parallel with each other, and the two second sides (A,B) are curved at least partially around a first longitudinal axis () defined by the first elongate hollow shape (). The structural member (), when in a deformed state, has a second elongate hollow shape (), different from the first elongate hollow shape (), in which the two second sides (A,B) are generally straight and parallel with each other, and the two first sides (A,B) are curved at least partially around a second longitudinal axis () defined by the second elongate hollow shape ().

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Raanana, Israel

Alon Shalev