Siemens Aktiengesellschaft

Roche Diagnostics Operations, Inc.

Roche Molecular Systems, Inc.

Roche Diagnositcs Operations, Inc.

Alois Rainer

Walter Ulbrich

Lajos Gazsi

Carlo S Effenhauser

Tobias Noll

Walter Eberle

Armin Bucher

Remo Anton Hochstrasser

Maximilian Ruhstorfer

Peter Berndt

Bernd Buchberger

Hanno Langen

Horst Donner

Christoph Hundt

Albert Roeder

Peter Hloch

Thomas Blaettler

Hans-Joachim Hoeltke

The invention concerns a method for isolating and purifying nucleic acids from large sample volumes and a device suitable for this. The device comprises a funnel, a separating column, and a tab which are detachable from each other. The method according to the invention in which the device according to the invention is used ensures a higher yield of nucleic acids.

Method and device for purifying nucleic acids

Pipette tip plate

The present invention relates to a device for separating a tissue part from brain material, the device comprising a circular blade which continues as the wall of a cylindrical or substantially cylindrical hollow body, at the end of which a grid is arranged perpendicular to the cylinder axis. The invention further relates to the use of the device in a method for separating a tissue part from brain material and to a kit containing one or more devices according to the invention.

Device for cutting out tissue specimens

A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation elementfor the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in areaof a separation plane. According to the invention it is proposed that the separation elementhas a channel or transfer structurefor the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surfacethat is preferably suitable for mass spectroscopic analyses.

Separation method and device for protein mixtures

A method and apparatus for preparing samples of a time-dependent signal (Se) in a data processing system which comprises an arithmetic unity (1), a control unit (2), a memory (3) and an address modification unit (13) wherein with a stored dataset of individual samples, for updating these step-by-step during every successive sampling period and respectively reading out the dated dataset and supplying it to the arithmetic unit (1), is achieved such that an address sequence which traverses a prescribed memory area is output via the address modification unit (13), so that a sequence of samples is written. Subsequently, the memory area is cyclically traversed with a plurality of address strings, whereby the stored samples are successively read out onto a bus line (4) and, when reaching an individual memory location within each of the address strings, the oldest sample stored there is overwritten by a further sample. The method is distinguished by a minimum of re-storing operations. The invention is used in signal processors, particularly those for filtering jobs.

Method and apparatus for reading samples of a time-dependent signal in a

A multiplication unit for n-place binary numbers has a first register containing the multiplicand, and accumulator, and an arithmetic unit having operand inputs connected to the first register and to the accumulator. The operation to be undertaken by the arithmetic unit is to find by the bits of a multiplier which is contained in a second register, the second register being connected to an operation instruction input of the arithmetic unit. A multiplexer having inputs connected to the outputs of the second register through-connects the bits of five adjacent multiplier places to the inputs of a logic circuit, which derives the operation instruction for the arithmetic unit. The logic circuit also supplies an instruction to a mulitple shift unit interconnected between the output of the arithmetic unit and the input of the accumulator.

Multiplication unit and method for the operation thereof

A digital arithmetic unit useful in data processing digital circuits comprises a plurality of stages each having two half-adders combined into a full adder and a carry logic element. An objective is to shorten the processing time for the addition and subtraction of binary numbers. For this purpose, the stages are divided into at least two groups and two separate carry paths are provided within each group. One of the carry paths is only switched on by means of selection logic elements. The activation occurs sequentially in group-wise fashion after simultaneous carry runs in all carry paths. The advantage particularly consists of the chronological coincidence of the carry runs in all groups.

Digital arithmetic unit having shortened processing time and a

A circuit for coding a binary number represented in two's complement in a CSD-code wherein it is impossible for two immediately adjacent binary digits to respectively exhibit a '1'. The circuit is simply constructed and has a high operating speed. This is achieved by means of a series of logic components which respectively evaluate according to an exclusive-OR function and which create an output bit -1 from two respectively adjacent binary digits of the number to be encoded upon appearance of the bit combination 1,0. A series of second logic components create a CSD-coded bit combination 0, 1 from two respectively adjacent first logic components having the output bits 1,-1, but which accept the output bits of the remaining first logic components into the CSD-coded bit combination in unaltered fashion. The circuit is used in signal processors.

Circuit for CSD-coding of a binary number represented in two's complement

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Munich, Germany

Alois Rainer