Kyorin Pharmaceutical Co., Ltd.

Dicerna Pharmaceuticals, Inc.

Allister Fraser

Bob Dale Brown

David Aaron Schwartz

Yasushi Kohno

Yi Hu

Akihiko Kojima

Sujit Basu

Junichi Ishiyama

Kevin Shreder

Sujit Kumar Basu

The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

Amine cationic lipids and uses thereof

Provided herein are benzoxazinone compounds of formula I and compositions containing the compounds. The compounds and compositions are useful in the methods of inhibiting the action of serine hydrolase, including neutrophil elastase. In certain embodiments, the compounds and compositions are useful in the prevention, amelioration or treatment of serine hydrolase-mediated diseases.

Serine hydrolase inhibitors

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Encinitas, CA, United States of America

Allister Fraser