The United States of America, As Represented by the Secretary, Department of Health and Human Services

Allison M Marrero

Thomas D Pfister

Robert J Kinders

Ralph E Parchment

James Halpern Doroshow

Monoclonal antibodies that specifically bind ataxia telangiectasia-mutated and RAD3-related kinase phosphorylated at position 1989 (pT1989 ATR), antigen binding fragments, conjugates thereof, and the use of these antibodies, antigen binding fragments and conjugates are disclosed herein. Also disclosed are nucleic acids encoding these antibodies, vectors including these antibodies, and isolated host cells transformed with these nucleic acids and vectors. Methods are also disclosed for using these antibodies, such as to detect pT1989 ATR, or to determine the dose of an agent of use to treat a subject. The antibodies are also of use for identifying ATR inhibitors.

Growing community of inventors

Gaithersburg, MD, United States of America

Allison M Marrero