General Electric Company

Purdue Research Foundation

Nanovis, LLC

Sabic Global Technolgoies B.v.

Allen Lawrence Garner

Vasile Bogdan Neculaes

Antonio Caiafa

Andrew Soliz Torres

Brian Duh-Lan Lee

Ram Anand Vadlamani

Brian Dun-Lan Lee

David Alan Detwiler

Gary Stephen Balch

Davide Louis Simone

Gregory John Parker

David Alexander Gibson, Iii

Harold Jay Patchen

Matthew Christian Nielsen

Siavash Yazdanfar

Daniel Qi Tan

Francis Johnson

Brian Michael Davis

Kenneth Roger Conway

Brent Allen Clothier

Todd Ryan Tolliver

Dmitry Vladimirovich Dylov

Evelina Roxana Loghin

Chulmin Joo

Nicole Evelyn LaPlante

Provided is a method of reducing a number of viable microbes, including contacting microbes with an antibiotic compound and applying pulses of electricity having a duration of between about 50 nanoseconds and about 900 nanoseconds. The pulses of electricity may have an intensity between about 20 kV/cm and about 40 kV/cm. The pulses of electricity may be applied at a frequency of between about 0.1 Hz and about 10 Hz. The microbes may be a gram-negative or a gram-positive strain of bacteria and the antibiotic may be applied at a concentration for a duration, wherein applying the antibiotic to the strain at the concentration for the duration does not reduce a viable number of bacteria of the strain as much, or at all, when the pulses of electricity are not also applied.

Inactivating bacteria with electric pulses and antibiotics

Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.

Platelet activation and growth factor release using electric pulses

In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.

Electric pulse generation system using capacitive coupling

Electric pulse generation systems using capacitive coupling

A composition for destructive interference in at least a portion of the frequency range from about 1 GHz to about 20 GHz can comprise a dielectric and a conductive filler mixed with at least a portion of the dielectric, wherein the percentage volume of the conductive filler relative to the total volume of the composition is configured such that the wavelength of sensitivity for the composition is on the order of a wavelength of an incident electromagnetic radiation in at least a portion of the frequency range from about 1 GHz to about 20 GHz.

Methods and compositions for destructive interference

A composition for energy dissipation in at least a portion of the frequency range from about 1 GHz to about 20 GHz, the composition can comprise a dielectric and graphene mixed with at least a portion of the dielectric, wherein the percentage volume of the graphene relative to the total volume of the composition is configured such that dissipation of incident electromagnetic radiation is substantially optimized in at least a portion of the frequency range from about 1 GHz to about 20 GHz.

Methods and compositions for energy dissipation

A pulse generation system for applying electric pulses across a load includes a first plurality of energy storage modules connected in series on a positive chain and configured to apply a positive potential to the load and a second plurality of energy storage modules connected in series on a negative chain and configured to apply a negative potential to the load. Each energy storage module of the positive chain and the negative chain includes a rectifier and a storage element, and at least one control element.

Modular adjustable pulse generator

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West Layfayette, IN, United States of America

Allen Lawrence Garner