Vistagen Therapeutics, Inc.

Cancer Advances, Inc.

Allen E Cato

H Ralph Snodgrass

Jack S Hicklin

Jill P Smith

Lynda Sutton

Brian Huber

Nicholas Osborne

Teresa Phillips

Provided are methods for preventing initiation and/or progression of gastrin-associated tumors and/or cancers in subjects. In some embodiments, the methods relate to administering compositions that gastrin immunogens to subjects. Also provided are methods for inhibiting development of gastrin-associated precancerous lesions, methods for preventing formation of fibrosis associated with a tumor and/or a cancer, uses of compositions that include a gastrin immunogen to prevent initiation and/or development of a gastrin-associated tumor or cancer and/or for preparing medicaments therefor, and compositions for use in preventing initiation and/or development of gastrin-associated tumors and/or cancers and/or precancerous lesions thereof.

Compositions and methods for preventing tumors and cancer

Provided are methods for sensitizing gastrin-associated tumors and/or cancers in subjects to inducers of humoral and cellular immune responses. In some embodiments, the methods relate to administering compositions that have anti-gastrin antibodies, gastrin peptides, and/or nucleic acids that inhibit expression of gastrin gene products to subjects. Also provided are methods for preventing, reducing, and/or eliminating the formation of fibroses associated with tumors and/or cancers, and methods for treating gastrin-associated tumors and/or cancers that include administering to subjects in need thereof a first agent that provides and/or induces an anti-gastrin humoral or cellular immune response in the subject and a second agent that includes one or more stimulators of cellular immune responses against the tumors and/or cancers.

Compositions and methods for inducing humoral and cellular immunities against tumors and cancer

Compositions of L-4-chlorokynurenine are provided, as are methods for the treatment of neurological dysfunction.

Dosage forms and therapeutic uses of L-4-chlorokynurenine

Compositions of L-4-chlorokynurenic are provided, as are methods for the treatment of neurological dysfunction.

Compositions of L-4-chlorokynurenine are provided, as are methods for the treatment of neurologica dyslinction.

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Durham, NC, United States of America

Allen E Cato