Cardiome Pharma Corp.

Stem Cell Therapeutics Inc.

Xortx Therapeutics, Inc.

Allen Davidoff

Doug Ta Hung Chou

Bertrand M C Plouvier

Aregahegn Yifru

James Gee Ken Yee

Lewis Siu Leung Choi

Peter Pang

Samuel Weiss

Alan M Ezrin

Grace Jung

Christopher Gregg

Jeffery Jerome Wheeler

Joseph Tucker

Jeffrey Jerome Wheeler

Adewale Eniade

Elizabeth L S Cheu

Bertrand Mc Plouvier

Taryn Bolvin

Disclosed herein are methods and compositions for involving a xanthine oxidase inhibitor that has enhanced solubility. The compositions described herein include a xanthine oxidase inhibitor combined with an organic base. The compositions can be used to treat a disease or medical condition that involves elevated uric acid levels.

Xanthine oxidase inhibitor formulations

The present invention provides effective dosing regimes for neural stem cell proliferating agents, kits containing effective dosing regimes for neural stem cell proliferating agents, and uses thereof. In particular, neural stem cell proliferating agents, such as hCG, prolactin and EPO are delivered to mammalian subjects at low doses in a continuous fashion over several days, as opposed to delivery of high doses in a short period of time.

Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents

This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same.

Deuterated aminocyclohexyl ether compounds and processes for preparing same

Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing such prodrugs. 

Prodrugs of ion channel modulating compounds and uses thereof

This invention is directed to drug conjugates of certain ion channel modulating compounds having the following formula: wherein A, X, R, R, R, R, R, LB, L and DM are defined herein, including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof. Pharmaceutical compositions and methods of use are also disclosed.

Drug conjugates of ion channel modulating compounds

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Calgary, Canada

Allen Davidoff