Mallinckrodt, Inc.

Mallinckrodt Medical, Inc.

Liebel-Flarsheim Company LLC

Allan R Bailey

David H White

Mills T Kneller

Michelle M Jones

Alexander N Petrov

Oliver Egan

Fiona Rooney

Thomas J Dunn

Michael J Gentilcore

Narciso Ocampo Doran, Iii

Sharad S Sathe

Derick L Kaspar

Robert E Vandas

Hung V Nguyen

Anna K Fukunaga

Richard C Wisneski

Andre T Spears

A process for the preparation of iosimenol comprising reacting 5,5'-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3&#x2032;-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.

Process for the preparation of iosimenol

A process for separating soluble silica species such as monomeric silicic acid (or monosilicic acid) and low molecular weight soluble polymeric silica from impure water soluble compounds by membrane nanofiltration is provided. A process for separating soluble silica species and colloidal silica from impure water soluble compounds by reverse phase liquid chromatography is also provided.

Removal of silica from water soluble compounds by nanofiltration and reverse phase chromatography

Process for producing ioversol

The reduction of the O-alkyl isomer content of 5-[N-(2-acetoxyethyl)acetoxyacetamido]-N,N'-bis(2,3-diacetoxypropyl)-2,4,6 -triiodoisophthalamide to thereby reduce and/or eliminate the production of impurities comparatively more difficult to remove during the purification of crude ioversol.

Synthesis of ioversol

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Ballwin, MO, United States of America

Allan R Bailey