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Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie

Neurochem (international) Limited

Theseus Imaging, Corp.

Leland Stanford Junior University

Institut Curie

Allan M Green

Francine Gervais

Robert Kisilevsky

Ludger Johannes

Francis G Blankenberg

Bruno Goud

Eric Tartour

H William Strauss

Wolf Herve Fridman

Neil Steinmetz

K Ramakrishnan Bhaskar

J Thomas Lamont

Strauss H W

Methods for stimulating an immune response in a mammal by administering a toxin-antigen conjugate are provided. Pharmaceutical compositions and methods for treating an antigen-related state are also described.

Verotoxin B subunit for immunization

The present invention provides methods and compositions for imaging cell death in vivo, as well as methods and compositions for tumor radiotherapy.

Methods for using annexin for detecting cell death in vivo and treating associated conditions

A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. Methods for tumor radiotherapy are also provided.

Method of imaging cell death in vivo

Compounds and methods for modulating cerebral amyloid angiopathy

Therapeutic compounds and methods for inhibiting a glycosaminoglycan (GAG)-associated molecular interaction in a subject, whatever its clinical setting, are described.

Methods and compositions to treat glycosaminoglycan-associated molecular interactions

Gastrointestinal mucus from patients suffering from cystic fibrosis has been found to contain large amounts of chondroitin sulfate polymer. This finding indicates that the enzyme chondroitinase is useful for preventing gastrointestinal mucus from accumulating in cystic fibrosis patients, and subjects suffering from other diseases or conditions characterized by excess mucus secretion.

Pharmaceutical compositions containing chondroitinase and uses therefor

A composition to be used in a method for imaging liver and for biliary function, the composition comprising a scanning agent that is combined with a radioisotope. The scanning agent is preferably a glycoprotein whose glycosidic side chains terminate in a sialic acid moiety followed by a galactose as exemplified by gamma globulin. The preferred radioisotope is technetium (.sup.99m Tc). The composition of the invention will bind to hepatocyte (liver cell) membranes whereas most known pertechnetated hepatic scanning agents attach to the reticuloendothelial cells of the liver (Kuppfer cells) with the advantage being that the present composition will be excreted into the bile ducts and make its way to the intestines, thus acting as an indicator of biliary tree patency. The composition has been administered to human subjects and animals for liver imaging using the anger camera as well as for evaluating the biliary function.

Scanning agent composition and use in imaging liver and for biliary

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Cambridge, MA, United States of America

Allan M Green