Symphogen A/s

Allan Jensen

Mikkel Wandahl Pedersen

Lucilla Steinaa

Per-Johan Meijer

Klaus Koefoed

Robert Carlsson

Charles Pyke

Johan Lantto

Lars Soegaard Nielsen

Søren Kofoed Rasmussen

Lone Kjær Rasmussen

Margit Haahr Hansen

Lars Sogaard Nielsen

Soegaard Nielsen

The present invention relates to novel therapeutic antibodies directed against HER2 (ErbB2), as well as recombinant polyclonal anti-HER2 antibody compositions comprising at least two of said recombinant anti-HER2 antibodies, and use of the antibodies and antibody compositions for treatment of cancer.

Anti-HER2 antibodies and compositions

The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides compositions or mixtures of antibodies capable of binding human EGFR. Antibody compositions with 3 or more antibodies showed synergy in reduction of proliferation of representative cancer cell lines. Advantageous results have also been obtained with a composition comprising two different chimeric anti-hEGFR antibodies which show a new mechanism of action based on rapid and efficient receptor internalisation, induction of terminal differentiation and subsequent tumour eradication in an animal model. The antibodies of the invention can be manufactured in one bioreactor as a polyclonal antibody.

Recombinant anti-epidermal growth factor receptor antibody compositions

Disclosed is an anti-orthopoxvirus recombinant polyclonal antibody comprising distinct members which in union are capable of binding at least three orthopoxvirus related antigens, a pharmaceutical composition comprising the antibody, and a method for its production. Also disclosed is a polyclonal cell line capable of producing the recombinant polyclonal antibody as therapeutic methods utilizing the polyclonal antibody. Finally, the invention also pertains to a method for screening for useful Vand Vpairs useful when preparing the polyclonal antibody.

Anti-orthopoxvirus recombinant polyclonal antibody

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Fredensborg, Denmark

Allan Jensen