Other

Protease Sciences Inc.

Aeromax Technologies, Inc.

Allan J Wachter

John Lezdey

Stuart Lindsay

Barry Starcher

Compositions and methods of treating disease and injuries wherein by sequentially or co-administering pulmonarily a polypeptide effective for the treatment of the injury or disease and a protease inhibitor capable of binding with elastase or cathepsin G.

Method of treatment

Cosmetic compositions and methods are provided for revitalizing the skin especially where it is placed in an environment which can cause injury to the skin. The compositions contain an effective amount of a protease inhibitor to provide a prophylactic or repairing effect.

Cosmetic compositions containing human type serine protease inhibitors

The invention provides an inhalation device for administering a medicament within a prescribed dosage range to avoid over or under administration. The device contains in the mouthpiece or nozzle a channel which follows the Poiseuille equation and provides a flow rate of the fluid containing the medicament at a flow rate of between 0.5 and 3.0 l/s.

Intrapulmonary delivery device

Compositions and methods are provided for treating the skin especially where it is placed in an environment which can cause injury or inflammation to the skin. The compositions contain an effective amount of the extract from marama beans.

Dermatological and cosmetic compositions containing marama bean extract

An intrapulmonary delivery device is provided for delivery of a propellant driven medicament. The device has an indicating system with a sensor responsive to a selected range of ultrasound, a controller associated with the sensor for signalling the detected ultrasound, a differential pressure sensor and a display for the signals. The controller is associated with a microprocessor where the signal level the duration and time of actuation is stored in memory.

MDI device with ultrasound sensor to detect aerosol dispensing

The invention relates to methods and compositions for the prevention or treatment of patients suffering from respiratory distress syndrome and/or sepsis syndrome by administering directly into the lungs small or nicrocrystalline particles or droplets of at least one protease inhibitor alone or with an oxygen metabolite scavenger. The method can also include the treatment in combination with the monitoring of the urine desmosine level of the patients and the use of DNase.

Treatment of pulmonary disease with protease inhibitors

The present invention provides a method for inhibiting viral proliferation by preventing or inhibiting viral replication or killing the viruses on contact. Viral replication is prevented or inhibited through the use of serine protease inhibitors, their analogs, salts, conjugates or derivatives.

Antiviral compositions and method of use

There is provided a method for treating tumors in mammals by the administration of alpha 1-antitrypsin alone or in combination with other protease inhibitors.

Treatment of mast cell tumors

Method for deactivating viruses in blood component containers

The invention provides a pharmaceutical composition for the treatment of a mammal having a skin disease. The composition contains a serine protease inhibitor and an effective amount of a cationic quaternary ammonium salt at a concentration below the critical micelle concentration for increasing the penetration of the inhibitor in the skin. Additionally, these may be included an ethoxylated nonylphenol.

Topical .alpha.-1-antitrypsin, non-aqueous lipid miscible, benzalkonium

A method for the prophylaxis or direct treatment of inflammatory diseases or injuries in a patient which comprises administering to the site of the disease or injury an effective amount of at least one serine protease inhibitor, its salts, derivatives or analogs which bind with the mast cell mediators, T-cell mediators or kallikrein.

Treatment of inflammation

A method for the prophylaxis or direct treatment of non-bronchial mast cell implicated diseases or injuries in a patient which comprises administering to the site of the disease or injury an effective amount of at least one serine protease inhibitor, its salts, derivatives or analogs which bind with the mast cells or their mediators.

A method for the prophylaxis or direct treatment of mast cell implicated pulmonary diseases which comprises administering an effective amount of a corticosteroid and at least one serine protease inhibitor, its salts, derivatives or analogs which bind with the mediators of mast cells or T-cells.

A method for the prophylaxis or direct treatment of dermatitis including psoriasis which comprises administering to the site of the disease an effective amount of a corticosteroid and a company which inhibits mast cells or binds with their mediators.

Treatment of psoriasis

A method for the prophylaxis or direct treatment of allergic rhinitis which comprises nasally administering to a patient an effective amount of a serine protease inhibitor which inhibits mast cells, neutrophiles or T-cells or binds with their mediators.

Growing community of inventors

Tempe, AZ, United States of America

Allan J Wachter