University of California

Other

Allan J Tobin

Mark G Erlander

Daniel L Kaufman

Michael J Clare-Salzler

Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed.

Cloned glutamic acid decarboxylase

The invention provides cDNA molecules comprising a part of the cDNA sequence of GADwhich encode at least one epitope for autoantibodies to GAD. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD. The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for GAD. In another embodiment, the invention provides for the detection of autoantibodies to GADusing the GADpolypeptides coded for by the cDNA molecules of the invention.

Nucleic acid encoding GAD65

cDNA molecules coding for GAD polypeptide are disclosed. The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD which encode at least one epitope for autoantibodies to GAD . The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD . The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for GAD . In another embodiment, the invention provides for the detection of autoantibodies to GAD using the GAD polypeptides coded for by the cDNA molecules of the invention.

Methods and kits useful for determining the status of and detecting pancreatic B-cell associated autoimmune diseases

The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD,which encode at least one epitope for autoantibodies to GAD,. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD,. The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for GAD,. In another embodiment, the invention provides for the detection of autoantibodies to GAD,using the GAD,polypeptides coded for by the cDNA molecules of the invention.

Isolated polypeptides useful in ameliorating GAD-associated autoimmune disease as well as diagnostic and therapeutic methods of using the peptides are disclosed. Monoclonal antibodies specific for GAD peptides and hybridoma cells producing such are also disclosed.

Hybridomas and monoclonal antibodies that specifically bind to glutamic

Method for ameliorating glutamic acid decarboxylase associated

Methods and kits useful for detecting autoantibody to glutamic acid

The invention is directed to isolated polypeptides useful in ameliorating autoimmune disease.

Cloned glutamic acid decarboxylase nucleic acids

Peptides derived from glutamic acid decarboxylase

Isolated polypeptides useful in ameliorating autoimmune disease.

Growing community of inventors

Los Angeles, CA, United States of America

Allan J Tobin