Beecham Group Plc

Allan Guildford Brown

Thomas T Howarth

Roger J Ponsford

David F Corbett

Compounds of the formula ##STR1## and salts and esters thereof wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms, phenyl, alkenyl of 2 to 4 carbon atoms, alkynyl of 2 to 4 carbon atoms, acyl of 1 to 4 carbon atoms, a carboxylic acid group or ester thereof of 1 to 7 carbon atoms, or alkyl of 1 to 4 carbon atoms substituted by 1 or 2 halogen atoms, hydroxyl, substituted hydroxyl, amino, protected amino, substituted thio of 1 to 7 carbon atoms, substituted sulphinyl of 1 to 7 carbon atoms, substituted sulphonyl of 1 to 7 carbon atoms, or by a carboxylic acid group or ester thereof of 1 to 7 carbon atoms;

Azabicycloheptanes

Substituted azetidinones having antibacterial activity and pharmaceutically acceptable salts and esters thereof and pharmaceutical compositions containing an antibacterially effective amount of such an azetidinone. A representative compound is methyl 3-(2'-hydroxyethyl)-7-oxo-1-aza-4-oxabicyclo[3,2,0]-heptane-2-carboxylate. The daily dosage is between 50 and 6,000 mg.

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Cranleigh, United Kingdom

Allan Guildford Brown