Nexgenix Pharmaceuticals, Inc.

Universitéde Strasbourg

Oncosynergy, Inc.

Allan E Rubenstein

Jin-Chen Yu

Ruihong Chen

Xiaodong Shen

Scott Stewart

Nicolas Winssinger

Sofia Barluenga

Marco Giovannini

A method for treating a neurofibroma, e.g. dermal neurofibroma, a subdermal neurofibroma, or a superficial plexiform neurofibroma, in a subject in need of such treatment is disclosed. The method comprises locally applying a composition to a neurofibroma either topically or intralesionally. This method does not encompass systemic administration of the composition to the subject to have an effect on the neurofibromas. Compositions useful for such treatments and methods of preparing the compositions are disclosed.

Local treatment of neurofibromas

The present invention provides compounds of formulae Ia, Ia', IIa, IIa&#x2032;, IIIa, IIIa&#x2032;, IVa, or Va and the therapeutic use thereof. The present invention also includes methods of treating NF2-deficient or NF1-deficient cells or neurodegenerative diseases with radicicol or its derivatives, such as one or more compounds of formula I, II, III, IV, V, Ia, Ia&#x2032;, IIa, IIa&#x2032;, IIIa, IIIa&#x2032;, IVa, or Va. Furthermore, the present invention is directed to methods of inhibiting the growth of NF2-deficient or NF1-deficient tumors. The methods comprise contacting NF2-deficient or NF1-deficient tumor cells with radicicol or its derivatives, such as one or more compounds of formula I, II, III, IV, V, Ia, Ia&#x2032;, IIa, IIa&#x2032;, IIIa, IIIa&#x2032;, IVa, or Va. The present invention is also directed to the combinational use of radicicol or its derivatives, such as one or more compounds of formula I, II, III, IV, V, Ia, Ia&#x2032;, IIa, IIa&#x2032;, IIIa, IIIa&#x2032;, IVa, or Va with at least one additional active agent, such as one or more HSP90 inhibitors.

Treatment of neurofibromatosis with radicicol and its derivatives

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New York, NY, United States of America

Allan E Rubenstein