Auburn University

Altimmune, Inc.

Allan E David

Henry J Baker

Kent R Van Kampen

M Scot Roberts

Aime K Johnson

Prachi Sangle

Barry Jay Yeh

Therapeutic or prophylactic compositions providing an active agent, such as an antigen or a vector that contains and expresses an antigen, encapsulated in or incorporated into a biodegradable polymeric particle are provided. The compositions can also provide an active agent that is not encapsulated in or incorporated into the biodegradable polymeric particle in order to provide an initial or prime delivery of the active agent. Particles or composites providing an active agent encapsulated by a first and second polymer are also provided, wherein polymers are distributed in a gradient from a core of the composite to a surface of the composite, and configured to provide a delayed release of the active agent by a period of 7 days to 6 months. Methods of producing composites are also provided. Pharmaceutical formulations providing a single dose composition are also provided, along with methods for administering the pharmaceutical compositions to a subject in need thereof a therapeutically effective amount of an active agent are provided.

Biodegradable polymeric particles encapsulating an active agent, pharmaceutical compositions and uses thereof

A method of separating magnetic nanoparticles is described. The method comprises placing the magnetic nanoparticles in a periodic magnetic field. The periodic magnetic field varies between a first magnetic field strength and a second magnetic field strength that is higher than the first magnetic field strength. The nanoparticles may be superparamagnetic iron oxide nanoparticles.

Methods for separation of magnetic nanoparticles

Growing community of inventors

Auburn, AL, United States of America

Allan E David