Xenon Pharmaceuticals Inc.

Genentech, Inc.

Alla Yurevna Zenova

Sultan Chowdhury

Shaoyi Sun

Qi Jia

Thilo Focken

Christoph Martin Dehnhardt

Michael Edward Grimwood

Michael Scott Wilson

Jean-Christophe Andrez

Brian Salvatore Safina

Ivan William Hemeon

Kristen Nicole Burford

Paul Robert Bichler

Daniel P Sutherlin

Daniel Fred Ortwine

Mikhail A Chafeev

Serguei Sviridov

Jianmin Fu

Shifeng Liu

Jianyu Sun

Mark Wood

Jonathan David Langille

Shannon Marie Decker

Abid Hasan

Wei Gong

Lauren Fraser

Nagasree Chakka

Robert Joseph Devita

Simon James Gauthier

Jean-Jacques Alexandre Cadieux

Jun M Li

Philippe Bergeron

Tom Hsieh

Verner Alexander Lofstrand

Tao Sheng

Syed Abid Hasan

James Philip Johnson, Jr

Charles Jay Cohen

Amy Frances Douglas

Zoran Cikojevic

James Roy Empfield

Jiuxiang Zhu

Zhiguo Liu

Andrew D White

Steven Sigmund Wesolowski

Chien-An Chen

Zaihui Zhang

David Earl Bogucki

Renata Marcella Oballa

James Philip Johnson

Jun Li

Jr Johnson James Philip

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents

Benzenesulfonamide compounds and their use as therapeutic agents

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Benzenesulfonamide compouds and their use as therapeutic agents

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

The invention provides novel compounds having the general formula: and pharmaceutically acceptable salts thereof, wherein the variables R, subscript n, ring A, X, L, subscript m, X, B, R, R, R, R, Rand Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

N-substituted benzamides and methods of use thereof

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

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Burnaby, Canada

Alla Yurevna Zenova