Sanofi

Bristol-myers Squibb Compnay

Alla Pritsker

Nicolas Baurin

Han Li

Dorothea Kominos

Govindan Subramanian

Matthew Davison

Xin Chen

Jie Zhang

Mohan Srinivasan

Arvind Rajpal

Stanley Richard Krystek, Jr

Yong Zhang

Gregory D Vite

Paul E Morin

Chetana Rao-Naik

Philip Janiak

Magali Mathieu

Virginie Lafont

Zheng Lin

Alexey Rak

Bruno Poirier

Francis Duffieux

Patrick Grailhe

Christopher Ryan Morgan

Cyril Daveu

A prodrugged antibody has a blocking moiety attached to a Cys on its heavy or light chain via a linker having a cleavable moiety. The blocking moiety inhibits binding of the antibody to its antigen. Cleavage of the cleavable moiety releases the blocking moiety and restores ability of the antibody to bind to its antigen.

Prodruggable antibodies, prodrugs thereof, and methods of use and making

The invention provides antibodies that specifically bind to Kallidin or des-Arg10-Kallidin. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-Kallidin or des-Arg10-Kallidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to modulate Kallidin or des-Arg10-Kallidin activity or detect Kallidin or des-Arg10-Kallidin or, either in vitro or in vivo, are also provided by the invention. The invention further provides methods of making antibodies that specifically bind to des-Arg-Bradykinin and des-Arg-Kallidin-like peptide.

Nucleic acids encoding antibodies to Kallidin and des-Arg-Kallidin and host cells comprising the same

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The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

Antibodies to plasminogen activator inhibitor-1 (PAI-1) and uses thereof

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Cambridge, MA, United States of America

Alla Pritsker