The Charles Stark Draper Laboratory, Inc.

Alla A Gimbel

Jeffrey T Borenstein

James Gillett Truslow

Jose A Santos

David J Carter

Eugene H Cook

Tirunelveli Subramaniam Sriram

William Whitcomb McFarland

Nathan Francis Moore

Daniel Doty

Louis Kratchman

Abigail June Spencer

John Joseph LeBlanc

Angela B Holton

David A Landis

Parshant Kumar

Clayton Morris

The present disclosure discusses a system and method that includes a microfluidic device that can be used in either an extracorporeal or implantable configuration. The device supports efficient and safe removal of carbon dioxide from the blood of patients suffering from respiratory disease or injury. The microfluidic device can be a multilayer device that includes gas channels and fluid channels. Distensible membranes within the device can affect a cross-sectional area of the blood channels.

Biomimetic microfluidic device for high efficiency carbon dioxide removal from patients at low blood flow rates

Systems and methods for conducting assays on tissue fragment samples including providing a suspension maintaining pump, and a plurality of fluid reservoirs, wherein the fluid reservoirs are configured to hold a volume of fluid. The fluid reservoirs are fluidically coupled to a microfluidic assay chip, wherein the microfluidic assay chip includes a plurality of parallel assay channels, a first inlet port for introduction of a tissue fragment sample into the microfluidic assay ship, and a second inlet port coupled to the fluid reservoir. Each channel of the microfluidic assay chip also includes a retention barrier configured to trap the tissue fragment sample such that the fluid perfuses through the tissue sample, as well as an outlet port fluidically coupled to a waste receptacle.

Microfluidic system for evaluation of chemotherapeutic and immunotherapeutic drugs

A mold for casting a micro-scale structure includes an upper surface including a first cavity having a first depth. A negative pattern for an array of micro-scale structures is defined in a surface of the first cavity. The mold includes at least one second cavity having a second depth defined in the cavity outside of the negative pattern for the array of micro-scale structures. The at least one second cavity defines a negative pattern for a standoff of the micro-scale structure. A fabric retaining frame is disposed in the first cavity.

Polymer microwedges and methods of manufacturing same

Systems and methods for culturing and monitoring, ex vivo, pharmacologic and metabolic response in a biological sample, including receiving at a fluidic apparatus the biological sample retrieved from the patient, retaining the biological sample within a channel of the fluidic apparatus, providing for the culture of the biological sample within the channel of the fluidic apparatus, flowing a fluid past the biological sample, retrieving and analyzing the fluid to determine a pharmacologic and/or metabolic response of the sample.

Apparatus for ex vivo microfluidic analysis of biologic samples

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Medford, MA, United States of America

Alla A Gimbel