Chroma Therapeutics Limited

Glaxosmithkline Intellectual Property Development Limited

Alistair David Graham Donald

Sanjay Ratilal Patel

David Festus Charles Moffat

Alan Hornsby Davidson

Alan Hastings Drummond

Stephen John Davies

Francesca Ann Mazzei

Francesca Ann Day

David Charles Festus Moffat

Kenneth William John Baker

David Festus Moffat

Andrew James Belfield

David Festus C Moffat

Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: wherein Q, V and W independently represent &#x2014;N&#x2550; or &#x2014;C&#x2550;; B is a divalent radical selected from (B1), (B2), (B3), (B4), (B5) and (B6). wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker1]- and -[Linker2]- independently represent a bond, or a divalent linker radical; and R is (a) a radical of formula RRCHNH&#x2014;Y-L-X&#x2014;(CH)&#x2014; or (b) a radical of formula R-L-Y&#x2014;(CH)&#x2014;.

Hydroxamates as inhibitors of histone deacetylase

Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers: 

Enzyme inhibitors

Compounds of formula (I) inhibit HDAC activity, wherein A, B and D independently represent &#x2550;C&#x2014; or &#x2550;N&#x2014;; W is a divalent radical &#x2014;CH&#x2550;CH&#x2014; or CHCH&#x2014;; Ris a carboxylic acid group (&#x2014;COOH), or an ester group which is hydrolysable by one or more intracellular carboxyesterase enzymes to a carboxylic acid group; Ris the side chain of a natural or non-natural alpha amino acid; z is 0 or 1; and Y, L, and Xare as defined in the claims. 

Compounds which inhibit members of the histone deacetylase family of enzymes and their use in the treatment of cell proliferative diseases

Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers. 

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Abingdon, United Kingdom

Alistair David Graham Donald