University of California

California Institute of Technology

Leland Stanford Junior University

Shockwatch, Inc.

Alissa M Fitzgerald

Robert H Grubbs

Thomas W Kenny

Renee M Thomas

Marshall Leedy Stoller

Hoyong Chung

Aaron Partridge

Phillip W Barth

Johannes Albertus Van Niekerk

Anthony N Fonk

Benjamin W Chui

Jospeh Kurth Reynolds

This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.

Targeting microbubbles

An impact indicator includes a micro-sensor having a mass element configured to move from a first position to a second position in response to receipt by the mass element of an impact event. The micro-sensor includes detection circuitry configured to change from a first state to a second state in response to movement of the mass element from the first position to the second position. The detection circuitry is prevented from returning to the first state in response to changing to the second state. A radio-frequency identification (RFID) module is coupled to the detection circuitry and is configured to output a value indicating that the mass element is in the second position. An activator element is configured to maintain the mass element in the first position until removal of the activator element from the micro-sensor.

Impact indicator

A micromachined accelerometer for measuring acceleration in a direction parallel with the plane of the accelerometer substrate. The accelerometer has a strain-isolation pedestal, a flexure attached to the pedestal, and a proof mass attached to the flexure. The pedestal is wider than the flexure and does not bend when the device is under acceleration. The pedestal serves to isolate the flexure from substrate strain which may be caused by device packaging or temperature variations. Preferably, the joint between the pedestal and flexure, and the joint between the flexure and proof mass are smoothed to prevent stress concentration. The joints have a radius of curvature of at least 1 micron. A piezoresistor is located in one sidewall of the flexure. Alternatively, two piezoresistors are located on the flexure, with one on each sidewall. In this embodiment, a center-tap connection is provided to the point where the two piezoresistors are connected. The present invention includes devices having two accelerometers with Large proof masses and two reference accelerometers having very small proof masses. The four accelerometers are electrically connected in a wheatstone bridge circuit. Also, in the embodiment having two piezoresistors on one flexure, two accelerometers (with a total of four piezoresistors) are electrically connected in a Wheatstone bridge circuit to provide accurate acceleration sensing.

In-plane micromachined accelerometer and bridge circuit having same

Growing community of inventors

San Francisco, CA, United States of America

Alissa M Fitzgerald