Smithkline Beecham Corporation

Anormed, Inc.

Alison Mary Badger

David Aaron Schwartz

Don Edgar Griswold

Wanda Bernadette High

John G Gleason

Gary James Bridger

Paul E Bender

Donald H Picker

John C Lee

Nabil Hanna

Klaus M Esser

Philip L Simon

Christopher K Mirabelli

Peter J Bugelski

Elaine N Cheeseman

Danuta J Herzyk

Michael J DiMartino

James W Dorman

Bartholomew J Votta

A pharmaceutical composition containing a non-specific (NS) suppressor cell inducing compound and cyclosporin A and a pharmaceutically acceptable carrier or diluent, and method of inducing an immunosuppressive effect in a mammal, including a hyman, in need thereof which comprises administering an effective dose of a non-specific suppressor cell inducing compound and cyclosporin A to such mammal.

Immunosuppressive compositions

Method of treating asthma

Invented is a method of treatment of psoriasis in a mammal in need thereof which comprises administering to such mammal an effective amount of a substituted azaspirane.

Methods of treating psoriasis employing substituted azaspiranes

Invented are methods of inhibiting the production of cytokines, particularly inhibiting the production of interleukin-1 and inhibiting the production of tumor necrosis factor in a mammal in need thereof which comprises administering to such mammal an effective amount of an azaspirane derivative.

Cytokine inhibitors

Methods of treating opportunistic infections with azaspiranes

Invented are substituted azaspirane compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to induce an immunosuppressive effect in a mammal in need thereof.

Immunomodulatory azaspiranes

Method for delaying aids in an HIV infected individual by administration

Inhibition of interleukin-1 and tumor necrosis factor production by

A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and an effective amount of an azaspirane derivative, a method of treating an animal in need of immunomodulation which comprises administering to such animal an effective amount of an azaspirane derivative, and certain azaspirane derivatives.

Growing community of inventors

Bryn Mawr, PA, United States of America

Alison Mary Badger