Other

Conopco, Inc.

University of Liverpool

Iota Nanosolutions Limited

Alison Jayne Foster

Steven Paul Rannard

James Long

Dong Wang

David John Duncalf

Andrew Cooper

Haifei Zhang

Andrew James Elphick

John Nicholas Staniforth

Andrew Owen

Erwin Werner Tareilus

Daniele Chauvin

Cornelis Paul Erik Van Der Logt

Afrodite Lourbakos

Asha Hassan Essa

The present invention provides a composition and an antiviral drug preparation, each comprising at least one water-insoluble antiviral drug and at least one water-soluble carrier material, wherein the water-insoluble antiviral drug is dispersed through the water-soluble carrier material in nano-disperse form. The present invention further provides processes for preparing the compositions and drug preparations, and also aqueous nano-dispersions obtained by combining water and the compositions.

Antiviral compositions

The invention provides a method for the preparation of a carrier liquid which comprises the steps of: (I) preparing a single phase solution comprising: (a) a solvent or a mixture of miscible solvents, (b) a liquid carrier material, which is soluble in solvent (a), and (c) a dopant material which is also soluble in solvent (a); (II) cooling (preferably freezing) the single phase solution produced in step (I) to a temperature at which at least both the solvent (a) and carrier material (b) become solid; and (III) removing solid solvent (a) from the cooled (frozen) single phase solution in vapor form, such that the remaining cooled (frozen) carrier material (b) and dopant material (c) are returned to ambient temperature thus providing a product of liquid carrier material (b) having dopant material (c) dispersed therein.

Method of preparing carrier liquids

Relating to antiviral compositions

A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.

Pharmaceutical compositions

A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.

Preparation of pharmaceutical compositions

A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier.

The invention provides a method for preparing water dispersible or water soluble porous bodies and the bodies themselves The bodies have an intrusion volume as measured by mercury porosimetry of at least about 3 ml/g and comprise a three dimensional open-cell lattice containing less than 10% by weight of a water soluble polymeric material and 5 to 90% by weight of a surfactant, with the proviso that said porous bodies are not spherical beads having an average bead diameter of 0.2 to 5 mm. The method comprises the steps of: a) providing an intimate mixture of the polymeric material and the surfactant in a liquid medium b) providing a fluid freezing medium at a temperature effective for rapidly freezing the liquid medium; c) cooling the liquid medium with the fluid freezing medium at a temperature below the freezing point of the liquid medium for a period effective to rapidly freeze the liquid medium; and d) freeze-drying the frozen liquid medium to form the porous bodies by removal of the liquid medium by sublimation.

Porous bodies and method of production thereof

Porous bodies which are soluble or dispersible in non-aqueous media comprising a three dimensional open-cell lattice containing (a) 10 to 70% by weight of a polymeric material which is soluble in water immiscible non-aqueous media and (b) 30 to 90% by weight of a surfactant, said porous bodies having an intrusion volume as measured by mercury porosimetry of at least 3 ml/g.

A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the opioid in the carrier.

Preparation of pharmaceutical formulations

Use of a compound of formula (I) where Ris a Calkylene linkage optionally substituted by a Calkyl group; Ris &#x2550;NH, &#x2014;NHor &#x2014;OH; Ris Calkyl optionally terminated by a hydroxy, phenyl or a 5- or 6-membered heterocyclic group such as furyl or N-imidazolyl and Ris H; or Rand Rtogether form a Calkylene linkage; to produce a topical refreshing or cooling sensation in a mammal such as a human. 

Thienopyrimidines as cooling agents

Water dispersible or water soluble porous bodies comprising a three dimensional open-cell lattice containing 10 to 95% by weight of a polymeric material which is soluble in water, and, less than 5% by weight of a surfactant, said porous bodies having an intrusion volume as measured by mercury porosimetry (as hereinafter described) of at least about 3 ml/g, and, with the proviso that said porous bodies are not spherical beads having an average bead diameter of 0.2 to 5 mm. And a method for making the same comprising the steps of: providing an intimate mixture of the polymeric material and any surfactant in a liquid medium: providing a fluid freezing medium at a temperature effective for rapidly freezing the liquid medium; cooling the liquid medium with the fluid freezing medium at a temperature below the freezing point of the liquid medium for a period effective to rapidly freeze the liquid medium; and freeze-drying the frozen liquid medium to form the porous bodies by removal of the liquid medium by sublimation.

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Wirral, United Kingdom

Alison Jayne Foster