Smithkline Beecham Corporation

Other

Alison Frances Chalker

James Raymond Brown

David John Holmes

Lisa Kathleen Shilling

Magdalena Zalacain

Christopher Michael Traini

Sanjoy Biswas

Karen Anne Ingraham

Min Wang

Richard Lloyd Warren

Deborah Dee Jaworski

John Edward Hodgson

Elizabeth Jane Lawlor

Stephanie Van Horn

David John Payne

Christine Marie Debouck

Andrew P Fosberry

Jeffrey L Mooney

John Peter Throup

Yi Yi Zhong

Jennifer E Ray

Alexander Philip Bryant

Michael Ovari

Maria Magdalena Zalacain Feliu

Nicola Gail Wallis

Leslie Marie Palmer

James Yigong Ge

Robert Dwayne Lunsford

The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.

Peptidyl t-RNA hydrolase (PTH)

A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desired site in the molecule, but does not require ligation. Also described is the use of this method for high throughput screening the resulting modified nucleic acid molecules.

Methods for producing modified nucleic acid molecules

The invention provides tarF polypeptides and DNA (RNA) encoding tarF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tarF polypeptides to screen for antibacterial compounds.

Tarf

The invention provides gcp polypeptides and polynucleotides encoding gcp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gcp polypeptides to screen for antibacterial compounds.

The invention provides spoIIIE polypeptides and DNA (RNA) encoding spoIIIE polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spoIIIE polypeptide for the protection against infection, particularly bacterial infections.

SpoIIIE

The invention provides spoIIIE polypeptides and DNA (RNA) encoding spoIIIE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spoIIIE polypeptides to screen for antibacterial compounds.

spoIIIE from Steptococcus pneumoniae

The invention provides MurB polypeptides and polynucleotides encoding MurB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurB polypeptides to screen for antibacterial compounds.

MurB

The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.

aroA

The invention provides spoIIIE polypeptides and DNA (RNA) encoding spIIIE polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spoIIIE polypeptide for the protection against infection, particularly bacterial infections.

SpoIIIe polynucleotides

The invention provides spoIIIE polypeptides and DNA (RNA) encodig spoIIIE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utlizng spoIIIE polypeptides to screen for antibacterial compounds.

Spoiiie

TarF

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Trappe, PA, United States of America

Alison Frances Chalker