Cancer Research Technology Limited

Alison E McGonagle

Allan Michael Jordan

James R Hitchin

Niall M Hamilton

Ian D Waddell

Kate Mary Smith

Colin P Hutton

Bohdan Waszkowycz

Bodhan Waszkowycz

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R, R, R, R, W, X, X, X, X, X, X, X, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

PARG inhibitory compounds

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R, R, R, R, R, W, X, X, X, X, X, X, X, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated. 

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R, R, R, R, R, W, X, X, X, X, X, X, X, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated. 

2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG

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Manchester, United Kingdom

Alison E McGonagle