Sorrento Therapeutics, Inc.

Other

Roche Diagnostics Gmbh

Vivasor, Inc.

Chembridge Corporation

Fal Diagnostics

F. Hoffmann-la Roche Ag

Alisher B Khasanov

Tong Zhu

Gang Chen

Thomas W Bell

Zhenwei Miao

Hong Zhang

Rima Kaddurah-Daouk

Yufeng Hong

Alexander Chucholowski

Sergey Zozulya

Heyue Zhou

John Dixon Gray

Vlad Edward Gregor

Jason Conrad Pickens

Rajendran Vairagoundar

Yahua Liu

Jinhua Chen

Alexander Wilhelm Chucholowski

Alexey Vyacheslavovich Anikin

Charles Chamchoumis Mikel

Luyong Jiang

Zheng Yan

Douglas Eric McGrath

Mohan Santhanam Thiruvazhi

Goverdhan Reddy Vavilala

Aleksander Kadushkin

Katherine Fells

Dylan Deng

Alexander Kadushkin

Fahad Mohammed Saleh Al Athel

Hong D Zhang

Jason C Pickens

Charles Mikel

Ranendran Vairagoundar

Alexey Anikin

There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second drug conjugate with a different drug to a Lys residue on the targeting protein.

Drug-conjugates with a targeting molecule and two different drugs

There is disclosed an antibody drug conjugate (ADC) having an IgG antibody that binds to a CD38 target conjugated at a Cys site in the hinge region of an IgG antibody. There is further disclosed a method for treating multiple myeloma comprising providing an effective amount of a CD38 ADC.

CD38 antibody drug conjugate

There is disclosed derivatives of amanitin conjugated to a targeting antibody to form an ADC (antibody drug conjugate).

Antibody drug conjugates having derivatives of amatoxin as the drug

There is disclosed a Dolastatin derivative, conjugated to an antibody, comprising a Dolastatin derivative moiety of Formula IV.

Antibody drug conjugates

Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use. 

Tyrosine kinase inhibitors

The present invention relates to compounds and more particularly to compounds which are useful for the determination of bicarbonate and the delivery of bicarbonate to a non-aqueous solution. The invention further relates to an optical sensor for the determination of bicarbonate in a liquid sample.

Bicarbonate receptor compounds

Methods and kits for determine arginine compounds are discussed. The methods and kits of the invention can be used for the diagnosis of arginine compound associated disorders.

Methods and kits for the detection of arginine compounds

Methods for the detection of creatine compound levels in body fluid samples are discussed. Portable kits capable of determining creatine levels using non-invasive and visually detectable methods are also included.

Diagnostic kit for detecting creatine levels

Multicyclic aromatic compounds and uses thereof

Growing community of inventors

Carlsbad, CA, United States of America

Alisher B Khasanov