10x Genomics, Inc.

Alireza Salmanzadeh

Rajiv Bharadwaj

Dagmar Walter

Tobias Daniel Wheeler

Mohammad Rahimi Lenji

Yiran Zhang

Martin Sauzade

Ivan Akhremichev

Lynna Chen

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.

Methods and systems for processing polynucleotides

Devices, systems, and their methods of use, for generating and collecting droplets are provided. The device includes a collection region comprising a side wall canted at an angle. The invention further provides multiplex devices that increase droplet formation.

Devices, systems, and methods for increasing droplet formation efficiency

Devices, systems, and their methods of use, for sorting or separating magnetic particles are provided. A magnetic source is disposed adjacent a flow path and exerts a magnetic field on magnetic particles in order to separate particles.

Methods and devices for magnetic separation in a flow path

Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.

Devices and systems incorporating acoustic ordering and methods of use thereof

Devices, systems, and their methods of use, for sorting droplets or particles are provided. A source of acoustic energy can be employed to sort droplets or particles of a desired and predictable property.

Methods and devices for sorting droplets and particles

Systems, and their methods of use, for sorting or separating magnetic particles are provided. A system having a magnetic module with features that mate with voids in a flow module exerts a magnetic field on magnetic particles to separate particles.

Methods and systems including flow and magnetic modules

Devices, systems, and their methods of use, for sorting or separating magnetic particles are provided. A magnetic source, e.g., with at least one sharp feature, can be employed to exert a strong magnetic field on magnetic particles in order to separate particles of a desired and predictable property.

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Pleasanton, CA, United States of America

Alireza Salmanzadeh