Regeneron Pharmaceuticals, Inc.

Alina Baum

Christos Kyratsous

George D Yancopoulos

Andrew J Murphy

William C Olson

Gang Chen

Neil E Stahl

Tammy T Huang

Robert Babb

Wen-Yi Lee

Johanna Hansen

Marine Malbec

Cindy Gerson

Thomas Nittoli

Lisa A Purcell

Wen-yi Lee

The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Anti-SARS-CoV-2-spike glycoprotein antibodies and antigen-binding fragments

The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to TMPRSS2 and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections or influenza virus infections).

Anti-TMPRSS2 antibodies and antigen-binding fragments

Provided herein are monoclonal antibodies, or antigen-binding fragments thereof, that bind to the influenza B hemagglutinin (HA) protein, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies are useful for inhibiting or neutralizing influenza B virus activity, thus providing a means of treating or preventing influenza infection in humans. Also provided is the use of one or more antibodies that bind to the influenza B HA for preventing viral attachment and/or entry into host cells. The antibodies may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.

Anti-hemagglutinin antibodies and methods of use thereof

Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with influenza, including VX-787 and derivatives thereof, baloxavir and derivatives thereof, and baloxavir marboxil and derivatives thereof, and protein (e.g., antibody) drug conjugates thereof.

Protein-antiviral compound conjugates

Anti-SARS-CoV-2-Spike glycoprotein antibodies and antigen-binding fragments

Growing community of inventors

Pleasantville, NY, United States of America

Alina Baum