Massachusetts Institute of Technology

The Broad Institute, Inc.

Renagade Therapeutics Management Inc.

Alim Ladha

Feng Zhang

Muthusamy Jayaraman

Omar O Abudayyeh

Jonathan S Gootenberg

Vladimir Presnyak

Han Altae-Tran

Guilhem Faure

Brian Goodman

Stephen Scully

Julia Joung

Mario Rodriguez Mestre

Devin Scott Quinlan

Inna Shcherbakova

Giedrius Gasiunas

Elisabeth Narayanan

Jonathan Strecker

The present disclosure provides methods and compositions comprising Cas TypeV programmable nucleases and lipid nanoparticles capable of delivering the Cas TypeV programmable nucleases and genome editing systems comprising same.

Gene editing components, systems, and methods of use

Disclosed are engineered retrons and methods of use such as to modify the genome of a host (e.g., mammalian) cell by delivering the engineered retron or the encoded ncRNA in vitro or in vivo to the host (e.g., mammalian) cell.

Engineered retrons and methods of use

Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.

Rapid diagnostics

Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.

Type V CRISPR-Cas systems and use thereof

Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

Crispr effector system based coronavirus diagnostics

The present application provides systems, methods and compositions used for targeted gene modification, targeted insertion, perturbation of gene transcripts, nucleic acid editing. Novel nucleic acid targeting systems comprise components of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems and transposable elements.

CRISPR-associated transposase systems and methods of use thereof

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Cambridge, MA, United States of America

Alim Ladha