Hoechst Aktiengesellschaft

Alihussein N Dohadwalla

Noel J De Souza

Bansi Lal

Horst Dornauer

Richard H Rupp

Bani K Bhattacharya

Hans-Harald Sedlacek

Gerhard Dickneite

Hans-Ulrich Schorlemmer

Yatendra Khandelwal

Sujata Vasudev Bhat

Vijay A Aroskar

Nandkumar K Dadkar

Jurgen Blumbach

Adolf D'Sa

Ramchandra G Naik

Ramanujam Rajgopalan

Samba Laxminarayan Kattige

Ashok K Gangopadbya

Noel John De Souza

Sadashiv M Mandrekar

Aftab D Lakdawalla

Virbala Shah

Roland Kurrle

Greta Moraes

Noel J deSouza

Julius Mascarenhas

Sadashiv S Mandrekar

The present invention relates to labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive ionotropic effect, an effect of lowering intraocular pressure and lowing blood pressure.

Labdane derivatives, a process for their preparation, and their use as

Pharmaceutical compositions comprising labdane diterpenoid derivatives and pyrimido(6,1-a)-isoquinolin-4-one derivatives when administered to the skin of a mammal or of the man increase the rate of terminal hair growth, stimulate the conversion of vellus hair to growth as terminal hair and arrest hair loss. They can be used for the treatment of several kinds of alopecia.

Pharmaceutical compositions comprising labdane diterpenoid derivatives

The present invention relates to polyoxygenated labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive inotropic effect, an effect of lowering intraocular pressure and lowering blood pressure.

The present invention relates to novel 4H-1-benzopyran-4-one derivatives, to processes for the preparation thereof and to their use as anti-inflammatory, analgesic, immuno-suppressive and anti-allergic agents. In particular, the present invention relates to novel compounds of the formula I, ##STR1## in which R.sub.1 is hydrogen, alkyl having 1 to 6 carbon atoms, arly-C.sub.1 -C.sub.4 -alkyl, substituted C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkyl-C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, aryl or carboxyl or an aldehyde or COO--C.sub.1 -C.sub.4 -alkyl group, R.sub.2 is hydrogen, alkyl having 1 to 6 carbon atoms, nitro, amino, di-C.sub.1 -C.sub.4 -alkylamino or a halogen, R.sub.3 is C.sub.1 -C.sub.4 -alkyl, substituted C.sub.1 -C.sub.4 -alkyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, aryl-C.sub.1 -C.sub.4 -alkyl, nitro, amino, a C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino group or halogen, R.sub.4 is hydrogen, hydroxyl, C.sub.1 -C.sub.4 -alkyoxy, C.sub.1 -C.sub.4 -alkyoxycarbonyl, aryloxy, amino or a C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino group, R.sub.5 is hydrogen, C.sub.1 -C.sub.6 -alkyl, substituted C.sub.1 -C.sub.6 -alkyl, aryl-C.sub.1 -C.sub.4 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkyl-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkanoyl or aroyl, the aryl group being phenyl which is unsubstituted, monosubstituted or polysubstituted, m is an integer between 0 and 3 and n is an integer between 0 and 2, and to pharmacologically acceptable acid addition salts thereof.

4H-1-benzopyran-4-one compounds which have anti-inflamatory or

The present invention relates to a process for the isolation of labdan derivatives from the plant Coleus forskohlii, and their use as medicaments having anti-inflammatory and analgesic activity.

Method of treating inflammatory diseases with labdan derivatives

The present invention relates to a compound of the formula ##STR1## and to a process for its isolation from plants of the family comprising the meliaceae. The compound has, in particular, immunosuppressive properties, and can therefore be used as a medicament.

Immunosuppressive chromone alkaloid

What are disclosed are pyrimido(6,1-a)isoquinolin-4-one compounds useful as hypotensive agents, bronchodilators, and anti-allergenics, intermediates useful in their preparation, and method for making the compounds and intermediates.

Pyrimido(6-1-a)isoquinolin-4-one derivatives

9,10-substituted-2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2H-pyrimido-(6,1 -a)isoquinoline-4-ones and salts thereof having hypotensive and vasodilating properties.

9,10-substituted

The possibility of using the diterpene derivative forskolin (1.alpha., 6.beta., 9.alpha.-trihydroxy-7.beta.-acetoxy-8,13-epoxy-14-labden-11-one) to increase the immunological responsiveness of mammals is described.

Use of the diterpene derivative forskolin for immunostimulation

What are disclosed are pyrimido (6,1-a)isoquinolin-4-one compounds useful as hypotensive agents, bronchodilators, and anti-allergenics, intermediates useful in their preparation, and methods for making the compounds and intermediates.

Pyrimido (6,1-a)isoquinolin-4-one derivatives

Hypotensively active triazino-(2,1-a)isoquinoline compounds having the ring system ##STR1## and methods of making and using such compounds.

Triazino(2,1-a)isoquinoline derivatives, compositions and their use as

This invention relates to a pharmacologically effective substance named Coleforsin, to a process for its preparation from plants belonging to the Labiatae family, and to pharmaceutical preparations containing it.

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Bombay, India

Alihussein N Dohadwalla