Regeneron Pharmaceuticals, Inc.

Alida Coppi

William C Olson

Peter W Mason

Christos Kyratsous

Brinda Prasad

Anna Zumsteg

Speciated antibodies or antigen-binding fragments that bind staphylococcal antigens are provided, where the antibodies and antigen-binding fragments have attenuated Fc binding to Protein A or homologous protein. Compositions comprising the antibodies and methods of use are also provided. The antibodies and compositions are useful for treating staphylococcal infection, reducing serum or kidney bacterial titers, and treating symptoms associated with staphylococcal infection. The antibodies may also prevent the severity and/or duration of the primary disease.

Anti-antibodies and uses thereof

The present disclosure provides antibodies and antigen-binding fragments of antibodies that bind toPcrV, and methods of using the same. According to certain embodiments, the disclosure includes antibodies and antigen-binding fragments of antibodies that bind PcrV. The anti-PcrV antibodies and antigen-binding fragments are useful for the prevention and treatment ofinfections.

Anti-PcrV antibodies that bind PcrV, compositions comprising anti-PcrV antibodies, and methods of use thereof

The present invention provides antibodies that bind toHemolysin A toxin, and methods of use. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Hemolysin A. The antibodies of the invention are useful for inhibiting or neutralizing Hemolysin A activity, thus providing a means of preventing or treating a Hemolysin A-related disease or disorder such asinfection. In some embodiments, the antibodies of the present invention are used in treating at least one symptom or complication of ainfection.

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Flushing, NY, United States of America

Alida Coppi